Information de reference pour ce titreAccession Number: | 00002328-201210020-00012.
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Author: | Osunkwo, Ifeyinwa 1,2; Ziegler, Thomas R. 3; Alvarez, Jessica 3; McCracken, Courtney 2; Cherry, Korin 1; Osunkwo, Chinyere E. 1; Ofori-Acquah, Solomon F. 1,2; Ghosh, Samit 2; Ogunbobode, Adeolu 2; Rhodes, Jim 1; Eckman, James R. 4,5; Dampier, Carlton 1,2; Tangpricha, Vin 3
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Institution: | (1) Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, USA (2) Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (3) Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA, USA (4) Department of Hematology Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA (5) Georgia Comprehensive Sickle Cell Center of Grady Memorial Hospital, Atlanta, GA, USA
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Title: | |
Source: | British Journal of Haematology. 159(2):211-215, October 2012.
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Abstract: | Summary: We report results of a pilot study of high-dose vitamin D in sickle cell disease (SCD). Subjects were given a 6-week course of oral high-dose cholecalciferol (4000-100 000 IU per week) or placebo and monitored prospectively for a period of six months. Vitamin D insufficiency and deficiency was present at baseline in 82[middle dot]5% and 52[middle dot]5% of subjects, respectively. Subjects who received high-dose vitamin D achieved higher serum 25-hydroxyvitamin D, experienced fewer pain days per week, and had higher physical activity quality-of-life scores. These findings suggest a potential benefit of vitamin D in reducing the number of pain days in SCD. Larger prospective studies with longer duration are needed to confirm these effects.
Copyright (C) 2012 Blackwell Publishing Ltd.
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Author Keywords: | vitamin D; chronic pain; sickle cell; paediatrics; quality of life.
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Language: | English.
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Document Type: | short report: Paediatric.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0007-1048
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NLM Journal Code: | axc, 0372544
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DOI Number: | https://dx.doi.org/10.1111/bjh.1...- ouverture dans une nouvelle fenêtre
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