Information de reference pour ce titreAccession Number: | 00002328-200206040-00010.
|
Author: | Roman, Viviana 1 1; Billard, Christian 1; Kern, Catherine 1; Ferry-Dumazet, Helene 2; Izard, Jean-Claude 3; Mohammad, Ramzi 4; Mossalayi, Djavad M 2; Kolb, Jean-Pierre 1
|
Institution: | (1)U.365 INSERM, Institut Curie, Paris, (2)Laboratoire d'Immunologie et Parasitologie, UFR des Sciences Pharmaceutiques, Universite Victor Segalen, Bordeaux, (3)Actichem, Montauban, France, and (4)Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA
|
Title: | |
Source: | British Journal of Haematology. 117(4):842-851, June 2002.
|
Abstract: | Summary. Trans-resveratrol was analysed for its apoptotic and growth inhibitory activity in human B-cell lines derived from chronic B-cell malignancies (WSU-CLL and ESKOL), and in leukaemic lymphocytes from patients with B-cell chronic lymphocytic leukaemia (B-CLL). Resveratrol displayed antiproliferative activity on both B-cell lines, as estimated by the decrease in cell recovery and inhibition of thymidine uptake. Furthermore, resveratrol induced apoptosis in the two cell lines as well as in B-CLL patients' cells, as evidenced by the increase in annexin V binding, caspase activation, DNA fragmentation and decrease of the mitochondrial transmembrane potential [DELTA][PSI]m. We previously reported that nitric oxide (NO), endogenously released by an iNO synthase (iNOS) spontaneously expressed in these leukaemic cells, contributed to their resistance towards apoptosis. We show here that resveratrol inhibited both iNOS protein expression and in situ NO release in WSU-CLL, ESKOL and B-CLL patients'cells. In addition, Bcl-2 expression was also inhibited by resveratrol. Thus, downregulation of the two anti-apoptotic proteins iNOS and Bcl-2 can contribute to the apoptotic effects of resveratrol in leukaemic B cells from chronic leukaemia. Our data suggest that this drug is of potential interest for the therapy of B-CLL.
(C) 2002 Blackwell Science Ltd.
|
Author Keywords: | resveratrol; chronic B-cell leukaemia; apoptosis; nitric oxide; Bcl-2.
|
References: | Bastianetto, S., Zheng, W.H. & Quirion, R. (2000) Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. British Journal of Pharmacology, 131, 711-720.
Bernhard, D., Tinhofer, I., Tonko, M., Hubl, H., Ausserlechner, M.J., Greil, R., Kofler, R. & Csordas, A. (2000) Resveratrol causes arrest in the S-phase prior to fas-independent apoptosis in CEM-C7H2 acute leukemia cells. Cell Death and Differentiation, 7, 834-842.
Carbo, N., Costelli, P., Baccino, F.M., Lopez-Soriano, F.J. & Argiles, J.M. (1999) Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model. Biochemical and Biophysical Research Communication, 254, 739-743.
Chan, M.Y., Mattiacci, J.A., Hwang, H.S., Shah, A. & Fong, D. (2000) Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Biochemical Pharmacology, 60, 1539-1548.
Chen, C.K. & Pace-Asciak, C.R. (1996) Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. General Pharmacology, 27, 363-366.
Clement, M.V., Hirpara, J.L., Chawdhury, S.H. & Pervaiz, S. (1998) Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood, 92, 996-1002.
Dorrie, J., Gerauer, H., Wachter, Y. & Zunino, S.J. (2001) Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Research, 61, 4731-4739.
Elattar, T.M. & Virji, A.S. (1999) The effect of red wine and its components on growth and proliferation of human oral squamous carcinoma cells. Anticancer Research, 19, 5407-5414.
Fremont, L. (2000) Biological effects of resveratrol. Life Science, 66, 663-673.
Gautam, S.C., Xu, Y.X., Dumaguin, M., Janakiraman, N. & Chapman, R.A. (2000) Resveratrol selectively inhibits leukemia cells: a prospective agent for ex vivo bone marrow purging. Bone Marrow Transplantation, 25, 639-645.
Hain, R., Reif, H.J., Krause, E., Langebartels, R., Kindl, H., Vornam, B., Wiese, W., Schmelzer, E., Schreier, P.H., Stocker, R.H. & Stenzel, K. (1993) Disease resistance results from foreign phytoalexin expression in a novel plant. Nature, 361, 153-156.
Harvey, W., Srour, E.F., Turner, R., Carey, R., Maze, R., Starrett, B., Kanagala, R., Pereira, D., Merchant, P., Taylor, M. & Jansen, J. (1991) Characterization of a new cell line (ESKOL) resembling hairy-cell leukemia: a model for oncogene regulation and late B-cell differentiation. Leukemia Research, 15, 733-744.
Hsieh, T.C. & Wu, J.M. (1999) Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines. Experimental Cell Research, 249, 109-115.
Hsieh, T.C., Burfeind, P., Laud, K., Backer, J.M., Traganos, F., Darzynkiewicz, Z. & Wu, J.M. (1999a) Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials. International Journal of Oncology, 15, 245-252.
Hsieh, T.C., Juan, G., Darzynkiewicz, Z. & Wu, J.M. (1999b) Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21 (WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2. Cancer Research, 59, 2596-2601.
Huang, C., Ma, W.Y., Goranson, A. & Dong, Z. (1999) Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. Carcinogenesis, 20, 237-242.
Hung, L.M., Chen, J.K., Huang, S.S., Lee, R.S. & Su, M.J. (2000) Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovascular Research, 47, 549-555.
Jang, M., Cai, L., Udeani, G.O., Slowing, K.V., Thomas, C.F., Beecher, C.W., Fong, H.H., Farnsworth, N.R., Kinghorn, A.D., Mehta, R.G., Moon, R.C. & Pezzuto, J.M. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science, 275, 218-220.
Kawada, N., Seki, S., Inoue, M. & Kuroki, T. (1998) Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology, 27, 1265-1274.
Kitada, S., Zapata, J.M., Andreeff, M. & Reed, J.C. (2000) Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. Blood, 96, 393-397.
Kolb, J.P. (2000) Mechanisms involved in the pro- and anti-apoptotic role of NO in human leukemia. Leukemia, 14, 1685-1694.
Kolb, J.P., Roman, V., Mentz, F., Zhao, H., Rouillard, D., Dugas, N., Dugas, B. & Sigaux, F. (2000) Contribution of nitric oxide to the apoptotic process in human B cell chronic lymphocytic leukemia. Leukemia and Lymphoma, 40, 243-257.
Koopman, G., Reutelingsperger, C.P., Kuijten, G.A., Keehnen, R.M., Pals, S.T. & van Oers, M.H. (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood, 84, 1415-1420.
MacCarrone, M., Lorenzon, T., Guerrieri, P. & Agro, A.F. (1999) Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity. European Journal of Biochemistry, 265, 27-34.
Mannick, J.B., Schonhoff, C., Papeta, N., Gafourifar, P., Szobor, M., Fang, K. & Gaston, B. (2001) S-Nitrosylation of mitochondrial caspases. The Journal of Cell Biology, 154, 111-116.
Mateo, V., Lagneaux, L., Bron, D., Biron, G., Armant, M., Delespesse, G. & Sarfati, M. (1999) CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia. Nature Medicine, 5, 1277-1284.
Mohammad, R.M., Mohamed, A.N., Hamdan, M.Y., Vo, T., Chen, B., Katato, K., Abubakr, Y.A., Dugan, M.C. & al-Katib, A. (1996) Establishment of a human B-CLL xenograft model: utility as a preclinical therapeutic model. Leukemia, 10, 130-137.
Park, J.W., Choi, Y.J., Suh, S.I., Baek, W.K., Suh, M.H., Jin, I.N., Min, D.S., Woo, J.H., Cang, J.S., Passaniti, A., Lee, Y.H. & Kwon, T.K. (2001) Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity. Carcinogenesis, 22, 1633-1639.
Pepper, C., Hoy, T. & Bentley, P. (1997) Bcl-2/Bas ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance. British Journal of Haematology, 96, 935-938.
Ragione, F.D., Cucciolla, V., Borriello, A., Pietra, V.D., Racioppi, L., Soldati, G., Manna, C., Galletti, P. & Zappia, V. (1998) Resveratrol arrests the cell division cycle at S/G2 phase transition. Biochemical and Biophysical Research Communication, 250, 53-58.
Reed, J.C. (1998) Molecular biology of chronic lymphocytic leukaemia. Seminars in Oncology, 25, 11-18.
Roman, V., Zhao, H., Fourneau, J.M., Marconi, A., Dugas, N., Dugas, B., Sigaux, F. & Kolb, J.P. (2000) Expression of a functional inducible nitric oxide synthase in hairy cell leukemia and ESKOL cell line. Leukemia, 14, 696-705.
Schwartz, D. (1963) Methodes statistiques a l'usage des medecins et biologistes. Flammarion Medecine-Sciences, Paris.
Stivala, L.A., Savio, M., Carafoli, F., Perucca, P., Bianchi, L., Maga, G., Forti, L., Pagnoni, U.M., Albini, A., Prosperi, E. & Vannini, V. (2001) Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol. Journal of Biological Chemistry, 276, 22586-22594.
Surh, Y.J., Hurh, Y.J., Kang, J.Y., Lee, E., Kong, G. & Lee, S.J. (1999) Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells. Cancer Letters, 140, 1-10.
Tessitore, L., Davit, A., Sarotto, I. & Caderni, G. (2000) Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21 (CIP) expression. Carcinogenesis, 21, 1619-1622.
Tinhofer, I., Bernhard, D., Senfter, M., Anether, G., Loeffler, M., Kroemer, G., Kofler, R., Csordas, A. & Greil, R. (2001) Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2. Federation of the American Societies for Experimental Biology Journal, 15, 1613-1615.
Tsai, S.H., Lin-Shiau, S.Y. & Lin, J.K. (1999) Suppression of nitric oxide synthase and the downregulation of the activation of NFkappaB in macrophages by resveratrol. British Journal of Pharmacology, 126, 673-680.
Tsan, M.F., White, J.E., Maheshwari, J.G., Bremner, T.A. & Sacco, J. (2000) Resveratrol induces Fas signalling-independent apoptosis in THP-1 human monocytic leukaemia cells. British Journal of Haematology, 109, 405-412.
Wadsworth, T.L. & Koop, D.R. (1999) Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages. Biochemical Pharmacology, 57, 941-949.
Zhao, H., Dugas, N., Mathiot, C., Delmer, A., Dugas, B., Sigaux, F. & Kolb, J.P. (1998) B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity. Blood, 92, 1031-1043.
|
Language: | English.
|
Document Type: | Haematological Malignancy.
|
Journal Subset: | Clinical Medicine.
|
ISSN: | 0007-1048
|
NLM Journal Code: | axc, 0372544
|
Annotation(s) | |
|
|