The effect of motilin on the rectum in healthy volunteers.
Kamerling, I. M. C.; Burggraaf, J.; van Haarst, A. D.; Oppenhuizen-Duinker, M. F.; Schoemaker, H. C.; Biemond, I. 1; Jones, R. 2; Heinzerling, H. 2; Cohen, A. F.; Masclee, A. A. M. 1
[Miscellaneous Article] British Journal of Clinical Pharmacology. 55(6):538-543, June 2003.

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Aims: The role of motilin in the regulation of upper gastrointestinal (GI) motility is well defined. However, little is known about the effects on the distal GI tract. To investigate the effect of exogenous motilin on rectal function, barostat measurements in the rectum were performed and lower abdominal symptoms were scored.

Methods: Eight fasted, healthy volunteers were infused intravenously with synthetic motilin or placebo over 90 min in a double-blind, randomized, cross-over design. Rectum volume was measured with a barostat device during constant pressure and during isobaric distensions. Lower abdominal symptoms were scored by visual analogue scales. Plasma motilin concentrations were measured by radioimmunoassay.

Results: Baseline rectum volumes were similar between treatments: 185 /- 62 mL (motilin) and 136 /- 41 mL (placebo). During the constant pressure procedure, motilin increased rectum volume [area under the effect curve (AUEC)] by 6%[95% confidence interval (CI) -3, 16] of baseline, compared with placebo. During isobaric distensions motilin increased rectum volume (AUEC) by 43 mL (95% CI 0.4, 85; P < 0.05) and compliance by 10 mL mmHg-1 (95% CI 0.3, 20; P < 0.05) relative to placebo. Motilin did not induce changes in the sensation of rectal feelings.

Conclusion: Exogenous motilin increased rectal compliance in healthy volunteers, without affecting rectal sensations.

(C) 2003 Blackwell Science Ltd.