The natural history of liver cirrhosis in HIV-hepatitis C virus-coinfected patients.
Lopez-Dieguez, Maria a; Montes, Maria L b; Pascual-Pareja, Jose F b; Quereda, Carmen c; Von Wichmann, Miguel A d; Berenguer, Juan e; Tural, Cristina g; Hernando, Asuncion f; Gonzalez-Garcia, Juan b; Serrano, Lucia h; Arribas, Jose R b; GESIDA 37/03-FIPSE 36465/03-NEAT IG5 Study Group
25(7):899-904, April 24, 2011.
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Objective: To provide detailed information about the natural history of HIV-hepatitis C virus (HCV)-coinfected patients with cirrhosis.
Methods: Prospective cohort including 340 HIV-HCV-coinfected patients with compensated (n = 248) or decompensated (n = 92) cirrhosis. We evaluated predictors of survival and of first hepatic decompensation.
Results: The mortality rate for patients with decompensated and compensated cirrhosis was 27.14 deaths per 100 person-years [95% confidence interval (CI) 18.93-35.35] and 3.98 deaths per 100 person-years (95% CI 2.42-5.54), respectively. Rate of first hepatic decompensation in patients with compensated cirrhosis was 4.62 per 100 persons-years (95% CI 2.91-6.33). In the complete cohort, permanent HAART interruption during follow-up, CD4 cell count nadir and baseline Child-Pugh score (CPS) B or C were significantly associated with shorter survival. In patients with compensated cirrhosis factors significantly associated with decreased survival were having the first hepatic decompensation during follow-up, permanent HAART discontinuation, and CPS B and C at baseline. For patients with compensated cirrhosis, time since diagnosis of HCV infection, CPS B and C and permanent HAART discontinuation were significantly associated with the risk of first hepatic decompensation. Sustained viral response to anti-HCV therapy was not independently associated with better survival in patients with compensated cirrhosis.
Conclusion: HIV-HCV-coinfected patients with cirrhosis have a relatively good 3-year survival (87%). In contrast, 2-year survival of patients with decompensated liver cirrhosis is only 50%. Three-year survival was mostly impacted by liver-related factors and HAART maintenance.
(C) 2011 Lippincott Williams & Wilkins, Inc.