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Poorly recognized by anatomists and pathologists is the cone-shaped zone of Muller cells that composes the central and inner part of the fovea centralis. The importance of these cells in the structural integrity of the macula, as a repository for xanthophyll, and in the pathogenesis of macular diseases, particularly regarding idiopathic macular hole and foveomacular schisis, is hypothesized.

Arch Ophthalmol.1999;117:821-823

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