Information de reference pour ce titreAccession Number: | 00000605-199810010-00002.
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Author: | Giovannucci, Edward MD, ScD; Stampfer, Meir J. MD, DrPH; Colditz, Graham A. MD, DrPH; Hunter, David J. MBBS, ScD; Fuchs, Charles MD, MPH; Rosner, Bernard A. PhD; Speizer, Frank E. MD; Willett, Walter C. MD, DrPH
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Title: | |
Source: | Annals of Internal Medicine. 129(7):517-524, October 1, 1998.
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Abstract: | Background: High intake of folate may reduce risk for colon cancer, but the dosage and duration relations and the impact of dietary compared with supplementary sources are not well understood.
Objective: To evaluate the relation between folate intake and incidence of colon cancer.
Design: Prospective cohort study.
Setting: 88 756 women from the Nurses' Health Study who were free of cancer in 1980 and provided updated assessments of diet, including multivitamin supplement use, from 1980 to 1994.
Patients: 442 women with new cases of colon cancer.
Measurements: Multivariate relative risk (RR) and 95% CIs for colon cancer in relation to energy-adjusted folate intake.
Results: Higher energy-adjusted folate intake in 1980 was related to a lower risk for colon cancer (RR, 0.69 [95% CI, 0.52 to 0.93] for intake >400 [micro sign]g/d compared with intake <or=to200 [micro sign]g/d) after controlling for age; family history of colorectal cancer; aspirin use; smoking; body mass; physical activity; and intakes of red meat, alcohol, methionine, and fiber. When intake of vitamins A, C, D, and E and intake of calcium were also controlled for, results were similar. Women who used multivitamins containing folic acid had no benefit with respect to colon cancer after 4 years of use (RR, 1.02) and had only nonsignificant risk reductions after 5 to 9 (RR, 0.83) or 10 to 14 years of use (RR, 0.80). After 15 years of use, however, risk was markedly lower (RR, 0.25 [CI, 0.13 to 0.51]), representing 15 instead of 68 new cases of colon cancer per 10 000 women 55 to 69 years of age. Folate from dietary sources alone was related to a modest reduction in risk for colon cancer, and the benefit of long-term multivitamin use was present across all levels of dietary intakes.
Conclusions: Long-term use of multivitamins may substantially reduce risk for colon cancer. This effect may be related to the folic acid contained in multivitamins.
This paper is also available at http//www.acponlinc.org.
: Ann Intern Med.1998;129:517-524.
(C) 1998 American College of Physicians
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Language: | English.
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Document Type: | Articles.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0003-4819
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NLM Journal Code: | 0372351, 5a6
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