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Endotracheal instillation of 0.1 N HCl in 19 anesthetized dogs caused a severe pulmonary reaction that resulted in hypoxia, hypercarbia, metabolic acidosis, hemoconcentration and death in 80 per cent of the animals. The resultant pulmonary damage was not altered morphologically or physiologically by high (30 mg/kg), low (0.3 mg/kg), or multiple (30 mg/kg every 8 hours for three days) doses of methylprednisolone administered intravenously.

(C) 1974 American Society of Anesthesiologists, Inc.