Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid(R).
Foxall, G. 1; McCahon, R. 2; Lamb, J. 3; Hardman, J. G. 4; Bedforth, N. M. 3
[Report] Anaesthesia. 62(5):516-518, May 2007.

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Summary: Lipid emulsion has been used in the successful treatment of local anaesthetic-induced cardiovascular collapse in animals and in two cases of cardiac arrest in humans. Previous reports of levobupivacaine toxicity in humans have been characterised by neurological signs and symptoms, without serious cardiovascular events. We present a case in which presumed intravenous injection of levobupivacaine led to neurological and cardiovascular consequences. This was treated successfully by resuscitation that included intravenous Intralipid(R) infusion.

(C) 2007 Association of Anaesthetists of Great Britain & Ireland