Eltrombopag to Treat Thrombocytopenia During Last Month of Pregnancy in a Woman With MYH9-Related Disease: A Case Report.
Favier, Remi MD *+; De Carne, Celine MD ++; Elefant, Elisabeth MD [S]; Lapusneanu, Ruxanda MD *+; Gkalea, Vasiliki MD [//]; Rigouzzo, Agnes MD [P]
10(1):10-12, January 1, 2018.
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MYH9-related disease (MYH9-RD) is an inherited rare autosomal dominant macrothrombocytopenia. Patients with MYH9-RD have giant platelets and leukocyte inclusion bodies caused by mutations in the MYH9 gene encoding the non-muscle myosin heavy chain II-A. Before identification of the causative gene, patients were diagnosed as Epstein or Fechtner or Sebastian syndromes or May-Hegglin anomaly. As with other inherited thrombocytopenias, the risk of increased bleeding during perioperative period or delivery is a major concern. We report here the first successful cesarean delivery of a woman with MYH9-RD treated with eltrombopag during the last month of pregnancy.
(C) 2018 International Anesthesia Research Society