Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial.
Eshleman, Susan H. MD, PhD; Hudelson, Sarah E. BS; Redd, Andrew D. PhD; Swanstrom, Ronald PhD; Ou, San-San MS; Zhang, Xinyi Cindy PhD; Ping, Li-Hua MD; Piwowar-Manning, Estelle BS MT (ASCP); Porcella, Stephen F. PhD; Sievers, Matthew F. BA; Martens, Craig A. PhD; Bruno, Daniel MSc; Dukhovlinova, Elena PhD; McCauley, Marybeth MPH; Gamble, Theresa PhD; Fogel, Jessica M. PhD; Sabin, Devin MSc; Quinn, Thomas C. MD; Gunde, Laurence MBBS; Maliwichi, Madalitso MBBS; Nhando, Nehemiah MBChB; Akelo, Victor MBChB, MPH; Moyo, Sikhulile MSc, MPH; Panchia, Ravindre MBBCh; Kumarasamy, Nagalingeswaran MBBS, PhD; Chotirosniramit, Nuntisa MD; Melo, Marineide Goncalves de MD, MSc; Pilotto, Jose MD; Grinsztejn, Beatriz MD, PhD; Mayer, Kenneth MD; Chen, Ying Q. PhD; Hughes, James P. PhD; Cohen, Myron S. MD
[Miscellaneous Article]
JAIDS Journal of Acquired Immune Deficiency Syndromes.
74(1):112-116, January 1, 2017.
(Format: HTML, PDF)
HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.
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