A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta.
Jang, Dae Sik 1; Lee, Ga Young 1; Kim, Junghyun 1; Lee, Yun Mi 1; Kim, Jong Min 1; Kim, Young Sook 1; Kim, Jin Sook 1
[Article]
Archives of Pharmacal Research.
31(5):666-670, May 2008.
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: A new coumaroyl triterpene, 3- O-trans-p-coumaroyl actinidic acid (1), as well as five known triterpenes, ursolic acid (2), 23-hydroxyursolic acid (3), corosolic acid (4), asiatic acid (5) and betulinic acid (6) were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structure of compound 1 was elucidated from interpretation of the spectroscopic data, particularly by extensive 1D and 2D NMR studies. All the isolates (1-6) were evaluated in vitro for their inhibitory activities on pancreatic lipase (PL). Of the isolates, the new compound 1 possessed the highest inhibitory activity on PL, with an IC50 of 14.95 [mu]M, followed by ursolic acid (2, IC50 = 15.83 [mu]M). The other four triterpenes (3-6) also showed significant PL inhibitory activity, with IC50 values ranging from 20.42 to 76.45 [mu]M.
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