Information de reference pour ce titreAccession Number: | 00006562-200604000-00006.
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Author: | Morris, Andrew B. Pharm.D., M.S.; Li, Jingjin Ph.D.; Kroenke, Kurt M.D.; Bruner-England, Tina E. Pharm.D.; Young, Jim M. Pharm.D.; Murray, Michael D. Pharm.D., M.P.H.
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Institution: | From the Department of Pharmacy Practice, PurdueUniversity School of Pharmacy and Pharmacal Sciences, Indianapolis, Indiana (Dr. Morris); the Regenstrief Institute, Inc., Indianapolis, Indiana (Drs. Morris, Kroenke, and Murray); the Department of Medicine, Indiana UniversitySchool of Medicine, Indianapolis, Indiana (Drs. Li and Kroenke); Wishard Health Services, Indianapolis, Indiana(Drs. Bruner-England and Young); and PharmaceuticalOutcomes and Policy Division and the Center for Pharmaceutical Outcomes and Policy, University of NorthCarolina School of Pharmacy at Chapel Hill, Chapel Hill, North Carolina (Dr. Murray).
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Title: | |
Source: | Pharmacotherapy:The Journal of Human Pharmacology & Drug Therapy. 26(4):483-492, April 2006.
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Abstract: | Study Objectives. To determine characteristics associated with drug adherence and blood pressure control among patients with hypertension, and to assess agreement between self-reported and refill adherences.
Design. Cross-sectional analysis of baseline data from an ongoing randomized controlled trial.
Setting. Primary care center at an urban, county health system in Indianapolis, Indiana.
Patients. Four hundred ninety-two participants with hypertension and taking at least one antihypertensive drug.
Measurements and Main Results. Social and demographic factors, comorbidity, self-reported drug adherence, prescription refill adherence, and systolic and diastolic blood pressures were recorded at baseline. Participants were aged 57 +/- 11 (mean +/- SD) years, were predominantly women (73%) and African-American (68%), and took 2.4 +/- 1.1 antihypertensive drugs. Agreement between self-reported and refill adherences was poor to fair ([kappa] = 0.21). On multiple logistic regression analysis, increased age (p<=0.002) and being married (p=0.03) were independent predictors of improved self-reported and refill adherence, whereas depressed patients had low self-reported adherence (p=0.005), and African-Americans had low refill adherence (p<0.001). Compared with nonadherent patients, adherent patients had lower systolic (-5.4 mm Hg by self-report and -5.0 mm Hg by refill) and diastolic (-2.7 mm Hg by selfreport and -3.0 mm Hg by refill) blood pressures (p<=0.02). Increased age was the only other variable strongly associated with systolic and diastolic blood pressure control in both measures of drug adherence (p<=0.001). The association of depression, race, and sex with blood pressure control was model dependent.
Conclusion. Age, sex, race and depression are associated with antihypertensive drug adherence and blood pressure control. Self-reported and refill adherences appear to provide complementary information and are associated with reductions in systolic and diastolic blood pressure of similar magnitude.
Copyright (C) 2006 John Wiley & Sons, Inc.
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Author Keywords: | drug adherence; compliance; persistence; hypertension.
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References: | 1. Fields LE, Burt VL, Cutler JA, Hughes J, Roccella EJ, Sorlie P. The burden of adult hypertension in the United States 1999 to 2000: a rising tide. Hypertension 2004;44:398-404.
2. Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 2003;289(19):2560-72.
3. Mendis S, Salas M. Hypertension. In: Sabate E, ed. Adherence to long-term therapies, evidence for action, 2003. Geneva, Switzerland: World Health Organization, 2003:107-14.
4. Eraker SA, Kirscht JP, Becker MH. Understanding and improving patient compliance. Ann Intern Med 1984; 100(2):258-68.
5. Goetzel RZ, Long SR, Ozminkowski RJ, Hawkins K, Wang S, Lynch W. Health, absence, disability, and presenteeism cost estimates of certain physical and mental health conditions affecting U.S. employers. J Occup Environ Med 2004;46(4): 398-412.
6. Ogden LG, He J, Lydick E, Whelton PK. Long-term absolute benefit of lowering blood pressure in hypertensive patients according to the JNC VI risk stratification. Hypertension 2000;35(2):539-43.
7. Maronde RF, Chan LS, Larsen FJ, Strandberg LR, Laventurier MF, Sullivan SR. Underutilization of antihypertensive drugs and associated hospitalization. Med Care 1989;27(12): 1159-66.
8. McDonald CJ, Overhage JM, Tierney WM, et al. The Regenstrief medical record system: a quarter century experience. Int J Med Inform 1999;54(3):225-53.
9. Haynes B, Taylor DW, Sackett DL. Compliance in health care. Baltimore: Johns Hopkins University Press, 1978.
10. Wang PS, Bohn RL, Knight E, Glynn RJ, Mogun H, Avorn J. Noncompliance with antihypertensive medications: the impact of depressive symptoms and psychosocial factors. J Gen Intern Med 2002;17(7):504-11.
11. Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol 1997;50(1):105-16.
12. Vik SA, Maxwell CJ, Hogan DB. Measurement, correlates, and health outcomes of medication adherence among seniors. Ann Pharmacother 2004;38(2):303-12.
13. Stroupe KT, Murray MD, Stump TE, Callahan CM. Association between medication supplies and healthcare costs in older adults from an urban healthcare system. J Am Geriatr Soc 2000;48(7):760-8.
14. Cargill JM. Medication compliance in elderly people: influencing variables and interventions. J Adv Nurs 1992;17(4):422-6.
15. Stroupe KT, Teal EY, Weiner M, Gradus-Pizlo I, Brater DC, Murray MD. Health care and medication costs and use among older adults with heart failure. Am J Med 2004;116(7):443-50.
16. Inui TS, Carter WB, Pecoraro RE. Screening for noncompliance among patients with hypertension: is self-report the best available measure? Med Care 1981;19(10):1061-4.
17. Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care 1986;24(1):67-74.
18. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 2001;16(9):606-13.
19. Kroenke K, Spitzer RL. The PHQ-9: a new depression diagnostic and severity measure. Psychiatr Ann 2003;32(9):1-7.
20. Grim CM, Grim CE. Blood pressure measurement. In: Izzo JL, Black HR, eds. Hypertension primer, 2nd ed. Dallas, TX: American Heart Association, 1999:295-8.
21. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16(1):31-41.
22. Sherbourne CD, Stewart AL. The MOS social support survey. Social Sci Med 1991;32(6):705-14.
23. Murray MD, Young JM, Morrow DG, et al. Methodology of an ongoing, randomized, controlled trial to improve drug use for elderly patients with chronic heart failure. Am J Geriatr Pharmacother 2004;2(1):53-65.
24. Ware JE, Sherbourne CD. The MOS 36 item short-form health survey: conceptual framework and item selection. Med Care 1992;30:473-83.
25. Ware JE, Kosisnski M, Keller SD. SF-36 physical and mental health summary scales: a users manual, 4th ed. Boston, MA: The Health Institute, 1994.
26. Starace F, Ammassari A, Trotta MP, et al. Depression is a risk factor for suboptimal adherence to highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2002;31(suppl 3):S136-9.
27. Knight EL, Bohn RL, Wang PS, Glynn RJ, Mogun H, Avorn J. Predictors of uncontrolled hypertension in ambulatory patients. Hypertension 2001;38(4):809-14.
28. DeVon HA, Powers MJ. Health beliefs, adjustment to illness, and control of hypertension. Res Nurs Health 1984;7(1):10-16.
29. Ford FM, Hunter M, Hensley MJ, et al. Hypertension and asthma: psychological aspects. Soc Sci Med 1989;29(1):79-84.
30. Bailey JE, Lee MD, Somes GW, Graham RL. Risk factors for antihypertensive medication refill failure by patients under Medicaid managed care. Clin Ther 1996;18(6):1252-62.
31. Waterhouse DM, Calzone KA, Mele C, Brenner DE. Adherence to oral tamoxifen: a comparison of patient selfreport, pill counts, and microelectronic monitoring. J Clin Oncol 1993;11(6):1189-97.
32. Eisen SA, Miller DK, Woodward RS, Spitznagel E, Przybeck TR. The effect of prescribed daily dose frequency on patient medication compliance. Arch Intern Med 1990;150(9):1881-4.
33. The Boston Consulting Group. The hidden epidemic: finding a cure for unfilled prescriptions and missed doses, December 2003. Available from www.bcg.com/publications/files/TheHiddenEpidemic_Rpt_HDec03.pdf. Accessed January 5, 2005.
34. Haynes RB, Taylor DW, Sackett DL, Gibson ES, Bernholz CD, Mukherjee J. Can simple clinical measurements detect patient noncompliance? Hypertension 1980;2(6):757-64.
35. Singh N, Squier C, Sivek C, Wagener M, Nguyen MH, Yu VL. Determinants of compliance with antiretroviral therapy in patients with human immunodeficiency virus: prospective assessment with implications for enhancing compliance. AIDS Care 1996;8(3):261-9.
36. Wang PS, Benner JS, Glynn RJ, Winkelmayer WC, Mogun H, Avorn J. How well do patients report noncompliance with antihypertensive medications?: a comparison of self-report versus filled prescriptions. Pharmacoepidemiol Drug Saf 2004;13(1):11-19.
37. Okuno J, Yanagi H, Tomura S, et al. Compliance and medication knowledge among elderly Japanese home-care recipients. Eur J Clin Pharmacol 1999;55(2):145-9.
38. Choo PW, Rand CS, Inui TS, Lee ML, Canning C, Platt R. A cohort study of possible risk factors for over-reporting of antihypertensive adherence. BMC Cardiovasc Disord 2001;1(1):1-6.
39. Billups SJ, Malone DC, Carter BL. The relationship between drug therapy noncompliance and patient characteristics, health-related quality of life, and health care costs. Pharmacotherapy 2000;20(8):941-9.
40. Gray SL, Mahoney JE, Blough DK. Medication adherence in elderly patients receiving home health services following hospital discharge. Ann Pharmacother 2001;35(5):539-45.
41. Botelho RJ, Dudrak R. Home assessment of adherence to longterm medication in the elderly. J Fam Pract 1992;35(1):61-5.
42. Spiers MV, Kutzik DM. Self-reported memory of medication use by the elderly. Am J Health-Syst Pharm 1995;52(9):985-90.
43. Spagnoli A, Ostino G, Borga AD, et al. Drug compliance and unreported drugs in the elderly. J Am Geriatr Soc 1989;37(7):619-24.
44. Monane M, Bohn RL, Gurwitz JH, Glynn RJ, Levin R, Avorn J. The effects of initial drug choice and comorbidity on antihypertensive therapy compliance: results from a population-based study in the elderly. Am J Hypertens 1997;10(7 pt 1):697-704.
45. Molassiotis A, Nahas-Lopez V, Chung WY, Lam SW, Li CK, Lau TF. Factors associated with adherence to antiretroviral medication in HIV-infected patients. Int J STD AIDS 2002;13(5):301-10.
46. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med 2000;160(14):2101-7.
47. Monane M, Bohn RL, Gurwitz JH, Glynn RJ, Avorn J. Noncompliance with congestive heart failure therapy in the elderly. Arch Intern Med 1994;154(4):433-7.
48. Jackevicius CA, Mamdani M, Tu JV. Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA 2002;288(4):462-7.
49. Avorn J, Monette J, Lacour A, et al. Persistence of use of lipid-lowering medications: a cross-national study. JAMA 1998;279(18):1458-62.
50. Romanelli J, Fauerbach JA, Bush DE, Ziegelstein RC. The significance of depression in older patients after myocardial infarction. J Am Geriatr Soc 2002;50(5):817-22.
51. Bosley CM, Corden ZM, Rees PJ, Cochrane GM. Psychological factors associated with use of home nebulized therapy for COPD. Eur Respir J 1996;9(11):2346-50.
52. Benner JS, Glynn RJ, Mogun H, Neumann PJ, Weinstein MC, Avorn J. Long-term persistence in use of statin therapy in elderly patients. JAMA 2002;288(4):455-61.
53. Rich MW, Gray DB, Beckham V, Wittenberg C, Luther P. Effect of a multidisciplinary intervention on medication compliance in elderly patients with congestive heart failure. Am J Med 1996;101(3):270-6.
54. Alfie J, Waisman GD, Galarza CR, Camera MI. Contribution of stroke volume to the change in pulse pressure pattern with age. Hypertension 1999;34(4 pt 2):808-12.
55. Haynes SG, Levine S, Scotch N, Feinleib M, Kannel WB. The relationship of psychosocial factors to coronary heart disease in the Framingham study, I: methods and risk factors. Am J Epidemiol 1978;107(5):362-83.
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Language: | English.
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Document Type: | Articles.
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Journal Subset: | Pharmacology.
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ISSN: | 0277-0008
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NLM Journal Code: | par, 8111305
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