Hematologic Changes and Hemoglobin Analysis in [beta] Thalassemia Heterozygotes during the First Year of Life.
WOOD, W. G.; WEATHERALL, D. J.; HART, G. H.; BENNETT, M.; MARSH, G. W.
[Article] Pediatric Research. 16(4):286-289, April 1982.

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Summary: We have studied the hematology and hemoglobin patterns of normal and heterozygous [beta] thalassemia infants in serial samples obtained during the first year of life. The hemoglobin level, mean cell volume and mean cell hemoglobin were significantly lower in the [beta] thalassemia traits by the age of 3 months and this difference was maintained throughout the first year. Hb A2 levels were significantly higher in the [beta] thalassemia group but increased in both groups throughout the first year. Hb F levels were also higher in heterozygotes for [beta] thalassemia at all ages, showing a delay in the postnatal decline.

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