Information de reference pour ce titreAccession Number: | 00006056-201701120-00039.
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Author: | The Cancer Genome Atlas Research Network; Analysis Working Group: Asan University; Kim, Jihun; BC Cancer Agency; Bowlby, Reanne; Mungall, Andrew J.; Robertson, Gordon A.; Brigham and Women's Hospital; Odze, Robert D.; Broad Institute; Cherniack, Andrew D.; Shih, Juliann; Pedamallu, Chandra Sekhar; Cibulskis, Carrie; Dunford, Andrew; Meier, Samuel R.; Kim, Jaegil; Brown University; Raphael, Benjamin J.; Wu, Hsin-Ta; Wong, Alexandra M.; Case Western Reserve University; Willis, Joseph E.; Dana-Farber Cancer Institute; Bass, Adam J.; Derks, Sarah; Duke University; Garman, Katherine; McCall, Shannon J.; Greater Poland Cancer Centre; Wiznerowicz, Maciej; Harvard Medical School; Pantazi, Angeliki; Parfenov, Michael; Institute for Systems Biology; Thorsson, Vesteinn; Shmulevich, Ilya; Dhankani, Varsha; Miller, Michael; KU Leuven; Sakai, Ryo; Mayo Clinic; Wang, Kenneth; Memorial Sloan Kettering Cancer Center; Schultz, Nikolaus; Shen, Ronglai; Arora, Arshi; Weinhold, Nils; Sanchez-Vega, Francisco; Kelsen, David P.; National Cancer Institute; Zhang, Julia; Felau, Ina; Demchok, John; Rabkin, Charles S.; Camargo, Constanza M.; Zenklusen, Jean Claude; Nationwide Children's Hospital; Bowen, Jay; Leraas, Kristen; Lichtenberg, Tara M.; Stanford University; Curtis, Christina; Seoane, Jose A.; University of Alabama; Ojesina, Akinyemi I.; University of Michigan; Beer, David G.; University of North Carolina; Gulley, Margaret L.; University of Pittsburgh; Pennathur, Arjun; Luketich, James D.; University of Rochester; Zhou, Zhongren; University of Southern California; Weisenberger, Daniel J.; University of Texas MD Anderson Cancer Center; Akbani, Rehan; Lee, Ju-Seog; Liu, Wenbin; Mills, Gordon B.; Zhang, Wei; University of Washington; Reid, Brian J; Van Andel Research Institute; Hinoue, Toshinori; Laird, Peter W.; Shen, Hui; Vanderbilt University; Piazuelo, Blanca M.; Schneider, Barbara G.; Washington University; McLellan, Michael; Genome Sequencing Center: Broad Institute; Taylor-Weiner, Amaro; Cibulskis, Carrie; Lawrence, Michael; Cibulskis, Kristian; Stewart, Chip; Getz, Gad; Lander, Eric; Gabriel, Stacey B.; Washington University in St. Louis; Ding, Li; McLellan, Michael D.; Miller, Christopher A.; Appelbaum, Elizabeth L.; Cordes, Matthew G.; Fronick, Catrina C.; Fulton, Lucinda A.; Mardis, Elaine R.; Wilson, Richard K.; Schmidt, Heather K.; Fulton, Robert S.; Genome Characterization Centers: BC Cancer Agency; Ally, Adrian; Balasundaram, Miruna; Bowlby, Reanne; Carlsen, Rebecca; Chuah, Eric; Dhalla, Noreen; Holt, Robert A.; Jones, Steven J. M.; Kasaian, Katayoon; Brooks, Denise; Li, Haiyan I.; Ma, Yussanne; Marra, Marco A.; Mayo, Michael; Moore, Richard A.; Mungall, Andrew J.; Mungall, Karen L.; Robertson, Gordon A.; Schein, Jacqueline E.; Sipahimalani, Payal; Tam, Angela; Thiessen, Nina; Wong, Tina; Broad Institute; Cherniack, Andrew D.; Shih, Juliann; Pedamallu, Chandra Sekhar; Beroukhim, Rameen; Bullman, Susan; Cibulskis, Carrie; Murray, Bradley A.; Saksena, Gordon; Schumacher, Steven E.; Gabriel, Stacey; Meyerson, Matthew; Harvard Medical School; Hadjipanayis, Angela; Kucherlapati, Raju; Pantazi, Angeliki; Parfenov, Michael; Ren, Xiaojia; Park, Peter J.; Lee, Semin; Kucherlapati, Melanie; Yang, Lixing; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University; Baylin, Stephen B.; University of North Carolina; Hoadley, Katherine A.; University of Southern California Epigenome Center; Weisenberger, Daniel J.; Bootwalla, Moiz S.; Lai, Phillip H.; Van Den Berg, David J.; Berrios, Mario; Holbrook, Andrea; University of Texas MD Anderson Cancer Center; Akbani, Rehan; Hwang, Jun-Eul; Jang, Hee-Jin; Liu, Wenbin; Weinstein, John N.; Lee, Ju-Seog; Lu, Yiling; Sohn, Bo Hwa; Mills, Gordon; Seth, Sahil; Protopopov, Alexei; Bristow, Christopher A.; Mahadeshwar, Harshad S.; Tang, Jiabin; Song, Xingzhi; Zhang, Jianhua; Van Andel Research Institute; Laird, Peter W.; Hinoue, Toshinori; Shen, Hui; Genome Data Analysis Centers: Broad Institute; Cho, Juok; Defrietas, Timothy; Frazer, Scott; Gehlenborg, Nils; Heiman, David I.; Lawrence, Michael S.; Lin, Pei; Meier, Samuel R.; Noble, Michael S.; Voet, Doug; Zhang, Hailei; Kim, Jaegil; Polak, Paz; Saksena, Gordon; Chin, Lynda; Getz, Gad; Brown University:; Wong, Alexandra M.; Raphael, Benjamin J.; Wu, Hsin-Ta; Harvard Medical School; Lee, Semin; Park, Peter J.; Yang, Lixing; Institute for Systems Biology; Thorsson, Vesteinn; Bernard, Brady; Iype, Lisa; Miller, Michael; Reynolds, Sheila M.; Shmulevich, Ilya; Dhankani, Varsha; Memorial Sloan Kettering Cancer Center; Abeshouse, Adam; Arora, Arshi; Armenia, Joshua; Kundra, Ritika; Ladanyi, Marc; Lehmann, Kjong-Van; Gao, Jianjiong; Sander, Chris; Schultz, Nikolaus; Sanchez-Vega, Francisco; Shen, Ronglai; Weinhold, Nils; Chakravarty, Debyani; Zhang, Hongxin; University of California Santa Cruz; Radenbaugh, Amie; University of Texas MD Anderson Cancer Center; Hegde, Apruva; Akbani, Rehan; Liu, Wenbin; Weinstein, John N.; Chin, Lynda; Bristow, Christopher A.; Lu, Yiling; Biospecimen Core Resource: International Genomics Consortium; Penny, Robert; Crain, Daniel; Gardner, Johanna; Curley, Erin; Mallery, David; Morris, Scott; Paulauskis, Joseph; Shelton, Troy; Shelton, Candace; The Research Institute at Nationwide Children's Hospital; Bowen, Jay; Frick, Jessica; Gastier-Foster, Julie M.; Gerken, Mark; Leraas, Kristen M.; Lichtenberg, Tara M.; Ramirez, Nilsa C.; Wise, Lisa; Zmuda, Erik; Tissue Source Sites: Analytic Biologic Services; Tarvin, Katherine; Saller, Charles; Asan Medical Center; Park, Young Soo; Asterand Bioscience; Button, Michael; Barretos Cancer Hospital; Carvalho, Andre L.; Reis, Rui Manuel; Matsushita, Marcus Medeiros; Lucchesi, Fabiano; de Oliveira, Antonio Talvane; BioreclamationIVT; Le, Xuan; Botkin Municipal Clinic; Paklina, Oxana; Setdikova, Galiya; Chonnam National University Medical School; Lee, Jae-Hyuck; Christiana Care Health System; Bennett, Joseph; Iacocca, Mary; Huelsenbeck-Dill, Lori; Cureline; Potapova, Olga; Voronina, Olga; Liu, Ouida; Fulidou, Victoria; Duke University; Cates, Crystal; Sharp, Alexis; Emory University; Behera, Madhusmitara; Force, Seth; Khuri, Fadio; Owonikoko, Taofeek; Pickens, Allan; Ramalingam, Suresh; Sica, Gabriel; Erasmus University; Dinjens, Winand; van Nistelrooij, Anna; Wijnhoven, Bas; Indiana University School of Medicine; Sandusky, George; Institute of Oncology of Moldova; Stepa, Serghei; International Genomics Consortium; Crain, Daniel; Paulauskis, Joseph; Penny, Robert; Gardner, Johanna; Mallery, David; Morris, Scott; Shelton, Troy; Shelton, Candace; Curley, Erin; Invidumed; Juhl, Hartmut; Israelitisches Krankenhaus Hamburg; Zornig, Carsten; Keimyung University School of Medicine; Kwon, Sun Young; Memorial Sloan Kettering Cancer Center; Kelsen, David; National Cancer Center Goyang; Kim, Hark Kyun; Ontario Tumour Bank; Bartlett, John; Parfitt, Jeremy; Chetty, Runjan; Darling, Gail; Knox, Jennifer; Wong, Rebecca; El-Zimaity, Haila; Liu, Geoffrey; Peter MacCallum Cancer Centre; Boussioutas, Alex; Pusan National University Medical School; Park, Do Young; Ribeirao Preto Medical School; Kemp, Rafael; Carlotti, Carlos Gilberto; da Cunha Tirapelli, Daniela Pretti; Saggioro, Fabiano Pinto; Sankarankutty, Ajith Kumar; Noushmehr, Houtan; dos Santos, Jose Sebastiao; Trevisan, Felipe Amstalden; St. Joseph's Hospital & Medical Center; Eschbacher, Jennifer; St. Petersburg Academic University; Dubina, Michael; Mozgovoy, Eugene; Tayside Tissue Bank; Carey, Frank; Chalmers, Sally; University of Dundee; Forgie, Ian; University of Kansas Medical Center; Godwin, Andrew; Reilly, Colleen; Madan, Rashna; Naima, Zaid; University of Michigan; Ferrer-Torres, Daysha; Vinco, Michele; University of North Carolina at Chapel Hill; Rathmell, Kimryn W.; University of Pittsburgh School of Medicine; Dhir, Rajiv; Luketich, James; Pennathur, Arjun; University of Texas MD Anderson Cancer Center; Ajani, Jaffer A.; Disease Working Group: Duke University; McCall, Shannon J.; Memorial Sloan Kettering Cancer Center; Janjigian, Yelena; Kelsen, David; Ladanyi, Marc; Tang, Laura; National Cancer Institute; Camargo, Constanza M.; University of Texas MD Anderson Cancer Center; Ajani, Jaffer A.; Yonsei University College of Medicine; Cheong, Jae-Ho; Data Coordination Center: CSRA Inc.; Chudamani, Sudha; Liu, Jai; Lolla, Laxmi; Naresh, Rashi; Pihl, Todd; Sun, Qiang; Wan, Yunhu; Wu, Ye; Project Team: National Institutes of Health; Demchok, John A.; Felau, Ina; Ferguson, Martin L.; Shaw, Kenna R. Mills; Sheth, Margi; Tarnuzzer, Roy; Wang, Zhining; Yang, Liming; Zenklusen, Jean Claude; Hutter, Carolyn M.; Sofia, Heidi J.; Zhang, Jiashan
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Institution: | (1)Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Songpa-gu, Seoul 05505, Korea (2)Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada (3)Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA (4)Department of Pathology, Harvard Medical School, Boston, Massachusetts 02215, USA (5)The Eli and Edythe L. Broad Institute of Massachusetts Institute Of Technology and Harvard University, Cambridge, Massachusetts 02142, USA (6)Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA (7)Department of Computer Science & Center for Computational Molecular Biology, Brown University, Providence, Rhode Island 02912, USA (8)Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA (9)Dept of Pathology, Case Medical Center, Cleveland, Ohio 44106, USA. (10)Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA (11)Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands (12)Department of Pathology, Duke University, Durham, North Carolina 27710, USA. (13)International Institute for Molecular Oncology, 60-203 Poznan, Poland (14)Greater Poland Cancer Centre, Poznan, 61-866, Poland (15)Poznan University of Medical Sciences, 61-866 Poznan, Poland (16)Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA (17)KEW Group Inc., Cambridge, Massachusetts 02139, USA. (18)Institute for Systems Biology, Seattle, Washington 98109, USA. (19)KU Leuven, Department of Electrical Engineering-ESAT(STADIUS), Leuven, Belgium (20)iMinds Medical IT, KU Leuven 3001, Belgium (21)Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA (22)Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA (23)Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA (24)Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA (25)Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA (26)National Cancer Institute, Bethesda, Maryland 20892, USA (27)Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA (28)The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205, USA (29)Department of Medicine, Division of Oncology and Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA (30)Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA (31)HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA (32)Department of Thoracic Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA (33)Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA (34)Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA (35)Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, New York 14642, USA (36)Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90033 USA (37)Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (38)Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA (39)Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (40)Fred Hutchinson Cancer Research Center, North Seattle, Washington 98109, USA (41)Center for Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA (42)Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA (43)McDonnell Genome Institute at Washington University, St. Louis, Missouri 63108, USA (44)Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA (45)Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA (46)Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63108, USA (47)Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA (48)Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA (49)Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA (50)Cancer Biology Division, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland 21231, USA (51)University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27514, USA (52)University of Southern California, USC/Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA (53)Department of Preventive Medicine, University of Southern California, Los Angeles, California 90033, USA (54)Institute for Personalized Cancer Treatment, Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (55)Department of Hemato-Oncology, Chonnam National University Medical School, Kwangju, Korea (56)Institute for Applied Cancer Science, Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA (57)Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA (58)University of California Santa Cruz Genomics Institute, Santa Cruz, California 95064, USA (59)International Genomics Consortium, Phoenix, Arizona 85004, USA (60)Analytical Biological Services, Inc., Wilmington, Delaware 19801, USA (61)Asterand Bioscience, Detroit, Michigan 48202, USA (62)Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil (63)Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal. (64)Department of Pathology, Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil (65)Department of Radiology, Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil (66)Department of Surgery, Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil (67)Department of Research Pathology, BioreclamationIVT, Chestertown, Maryland 21620, USA (68)Botkin Municipal Clinic, Moscow 125284, Russia (69)Department of Pathology, Chonnam National University Medical School, Hwasun, Republic of Korea (70)Helen F Graham Cancer Center & Research Institute, Christiana Care Health System, Newark, Delaware 19713, USA (71)Cureline Inc, South San Francisco, California 94080, USA (72)Emory University and Winship Cancer Institute, Atlanta, Georgia 30322, USA (73)Department of Pathology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, 3000 CA Rotterdam, The Netherlands (74)Department of Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands (75)Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands (76)Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA (77)Institute of Oncology of Moldova, Chisinau, Moldova (78)Indivumed GmbH, 20251 Hamburg, Germany (79)Israelitisches Krankenhaus Hamburg, 22297 Hamburg, Germany (80)Department of Pathology, Keimyung University School of Medicine, Daegu, Republic of Korea (81)Center for Gastric Cancer, National Cancer Center, Goyang, Republic of Korea (82)Ontario Tumour Bank, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada (83)Ontario Tumour Bank, London Health Science Centre, London N6A 5A5, Canada (84)Princess Margaret Cancer Centre, Toronto, Ontario M5G2M9, Canada (85)Sir Peter MacCallum Cancer Department of Oncology, University of Melbourne, Melbourne 3002, Australia (86)Department of Pathology, Pusan National University Medical School, Pusan, Republic of Korea (87)Department of Surgery and Anatomy, Ribeirao Preto Medical School-FMRP, University of Sao Paulo, 14049-900, Brazil (88)Department of Pathology, Ribeirao Preto Medical School-FMRP, University of Sao Paulo, 14049-900, Brazil (89)Department of Genetics, Ribeirao Preto Medical School-FMRP, University of Sao Paulo, 14049-900, Brazil (90)Department of Pathology, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA (91)St. Petersburg Academic University RAS, St. Petersburg 194021, Russia (92)Tayside Tissue Bank, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK (93)University of Kansas Medical Center, Kansas City, Kansas 66160, USA (94)Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA (95)Department of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA (96)Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA (97)Department of GI Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (98)Department of Surgery, Yonsei University College of Medicine, Seoul, 120-752, Korea (99)Leidos Biomedical, Rockville, Maryland 20850, USA (100)CSRA Inc., Falls Church, Virginia 22042, USA (101)National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
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Title: | Integrated genomic characterization of oesophageal carcinoma.[Article]
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Source: | Nature. 541(7636):169-175, January 12, 2017.
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Abstract: | : Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus. Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas. Oesophageal adenocarcinomas strongly resembled the chromosomally unstable variant of gastric adenocarcinoma, suggesting that these cancers could be considered a single disease entity. However, some molecular features, including DNA hypermethylation, occurred disproportionally in oesophageal adenocarcinomas. These data provide a framework to facilitate more rational categorization of these tumours and a foundation for new therapies.
(C) 2017 Nature Publishing Group
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Language: | English.
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Document Type: | ARTICLE.
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Journal Subset: | Life & Biomedical Sciences. Science.
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ISSN: | 0028-0836
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NLM Journal Code: | 0410462, nsc
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DOI Number: | https://dx.doi.org/10.1038/natur...- ouverture dans une nouvelle fenêtre
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