Crystal structure of the p27 sup Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Russo, Alicia A.; Jeffrey, Philip D.; Patten, Andrea K.; Massague, Joan; Pavletich, Nikola P.
[Article]
Nature.
382(6589):325-331, July 25, 1996.
(Format: HTML)
The crystal structure of the human p27 sup Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 Angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP.
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