Transposons and integrons in colistin-resistant clones of Klebsiella pneumoniae and Acinetobacter baumannii with epidemic or sporadic behaviour.
Arduino, Sonia M. 1; Quiroga, Maria Paula 2; Ramirez, Maria Soledad 2; Merkier, Andrea Karina 2; Errecalde, Laura 3; Di Martino, Ana 4; Smayevsky, Jorgelina 1; Kaufman, Sara 3; Centron, Daniela 2
Journal of Medical Microbiology.
61(10):1417-1420, October 2012.
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Multiple transposons, integrons and carbapenemases were found in Klebsiella pneumoniae colistin-resistant isolates as well as a genomic resistance island of the AbaR type in Acinetobacter baumannii colistin-resistant isolates from different hospitals from Buenos Aires City. PFGE analysis showed a polyclonal dissemination of antimicrobial resistance mechanisms among K. pneumoniae isolates, while in A. baumannii isolates the epidemic clone 1 from South America was found. Resistance determinants associated with horizontal gene transfer are contributing to the evolution to pandrug resistance in both epidemic and sporadic clones.
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