Information de reference pour ce titreAccession Number: | 00003086-201711000-00031.
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Author: | Lee, Jae Hoo MD 1; Han, Chang Dong MD, PhD 3; Cho, Sang-Nae DVM, PhD 2; Yang, Ick Hwan MD, PhD 1; Lee, Woo Suk MD, PhD 1; Baek, Seung-Hun PhD 2; Shin, Jae Won MD 1; Husein, Khalid Elfadil Ibrahim MD 4; Park, Kwan Kyu MD, PhD 1,a
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Institution: | (1)Department of Orthopaedic Surgery, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-gu, 120-752, Seoul, Korea (2)Department of Microbiology and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea (3)Department of Orthopaedic Surgery, Seoul Bumin Hospital, Seoul, Korea (4)Department of Trauma and Orthopaedic Surgery, Kosti Teaching Hospital, Kosti, Sudan
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Title: | |
Source: | Clinical Orthopaedics & Related Research. 475(11):2795-2804, November 2017.
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Abstract: | Background: Antibiotic-loaded bone cement is accepted as an effective treatment modality for musculoskeletal tuberculosis. However, comparative information regarding combinations and concentrations of second-line antimycobacterial drugs, such as streptomycin and amoxicillin and clavulanic acid, are lacking.
Questions/Purposes: (1) In antibiotic-loaded cement, is there effective elution of streptomycin and Augmentin(R) (amoxicillin and clavulanic acid) individually and in combination? (2) What is the antibacterial activity duration for streptomycin- and amoxicillin and clavulanic acid -loaded cement?
Methods: Six different types of bone cement discs were created by mixing 40 g bone cement with 1 or 2 g streptomycin only, 0.6 g or 1.2 g Augmentin(R) (amoxicillin and clavulanic acid) only, and a combination of 1 g streptomycin plus 0.6 g amoxicillin and clavulanic acid and 2 g streptomycin plus 1.2 g amoxicillin and clavulanic acid. Five bone discs of each type were incubated in phosphate buffered saline for 30 days with renewal of the phosphate buffered saline every day. The quantity of streptomycin and/or amoxicillin and clavulanic acid in eluates were measured by a liquid chromatography-mass spectrometry system, and the antimycobacterial activity of eluates against Mycobacterium tuberculosis H37Rv, were calculated by comparing the minimal inhibitory concentration of each eluate with that of tested drugs using broth dilution assay on microplate.
Results: Streptomycin was detected in eluates for 30 days (in 1 g and 2 g discs), whereas 1.2 g amoxicillin and clavulanate eluted until Day 7 and 0.6 g amoxicillin and clavulanate until Day 3. All eluates in streptomycin-containing discs (streptomycin only, and in combination with amoxicillin and clavulanic acid) had effective antimycobacterial activity for 30 days, while amoxicillin and clavulanate-only preparations were only active until Day 14. The antimycobacterial activity of eluates of 2 g streptomycin plus 1.2 g amoxicillin and clavulanate were higher than those of discs containing 1 g streptomycin plus 0.6 g amoxicillin and clavulanate until Day 3, without differences (Day 3, 1 g streptomycin plus 0.6 g amoxicillin and clavulanate: 17.5 +/- 6.85 ug/mL; 2 g streptomycin plus 1.2 g amoxicillin and clavulanate: 32.5 +/- 16.77 ug/mL; p = 0.109). After Day 7, however, values of the two combinations remained no different than that of Day 30 (Day 30, 1 g streptomycin plus 0.6 g amoxicillin and clavulanate: 0.88 +/- 0.34 ug/mL; 2 g streptomycin plus 1.2 g amoxicillin and clavulanate: 0.59 +/- 0.94 ug/mL; p = 0.107).
Conclusions: Streptomycin, in the form of antibiotic-loaded bone cement, had effective elution characteristics and antimycobacterial effects during a 30-day period, whereas amoxicillin and clavulanate only had effective elution and antimycobacterial characteristics during the early period of this study. The two drugs did not interfere with each other during the elution test.
Clinical Relevance: This research revealed that combinations of streptomycin and amoxicillin and clavulanate mixed with bone cement are effective for 30 days. Further trials to determine various different combinations of drugs are necessary to improve the effectiveness of treatments for musculoskeletal tuberculosis.
(C) 2017 Lippincott Williams & Wilkins LWW
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References: | 1. Aeng ES, Shalansky KF, Lau TT, Zalunardo N, Li G, Bowie WR, Duncan CP. Acute kidney injury with tobramycin-impregnated bone cement spacers in prosthetic joint infections. Ann Pharmacother. 2015;49:1207-1313 10.1177/1060028015600176.
2. Ahmed I, Jabeen K, Inayat R, Hasan R. Susceptibility testing of extensively drug-resistant and pre-extensively drug-resistant Mycobacterium tuberculosis against levofloxacin, linezolid, and amoxicillin-clavulanate. Antimicrob Agents Chemother. 2013;57:2522-2525 10.1128/AAC.02020-123716178.
3. Ahmed MM, Velayati AA, Mohammed SH. Epidemiology of multidrug-resistant, extensively drug resistant, and totally drug resistant tuberculosis in Middle East countries. Int J Mycobacteriol. 2016;5:249-256 10.1016/j.ijmyco.2016.08.008.
4. Amin TJ, Lamping JW, Hendricks KJ, McIff TE. Increasing the elution of vancomycin from high-dose antibiotic-loaded bone cement: a novel preparation technique. J Bone Joint Surg Am. 2012;94:1946-1951 10.2106/JBJS.L.00014.
5. Babalola CP, Patel KB, Nightingale CH, Nicolau DP. Synergistic activity of vancomycin and teicoplanin alone and in combination with streptomycin against Enterococcus faecalis strains with various vancomycin susceptibilities. Int J Antimicrob Agents. 2004;23:343-348 10.1016/j.ijantimicag.2003.09.017.
6. Bhusal Y, Shiohira CM, Yamane N. Determination of in vitro synergy when three antimicrobial agents are combined against Mycobacterium tuberculosis. Int J Antimicrob Agents. 2005;26:292-297 10.1016/j.ijantimicag.2005.05.005.
7. Brock HS, Moodie PG, Hendricks KJ, McIff TE. Compression strength and porosity of single-antibiotic cement vacuum-mixed with vancomycin. J Arthroplasty. 2010;25:990-997 10.1016/j.arth.2009.06.027.
8. Bryan WJ, Doherty JH Jr, Sculco TP. Tuberculosis in a rheumatoid patient: a case report. Clin Orthop Relat Res. 1982;171:206-208.
9. Campos OP. Bone and joint tuberculosis and its treatment. J Bone Joint Surg Am. 1955;37:937-966 10.2106/00004623-195537050-00004.
10. Chambers HF, Kocagoz T, Sipit T, Turner J, Hopewell PC. Activity of amoxicillin/clavulanatein patients with tuberculosis. Clin Infect Dis. 1998;26:874-877 10.1086/513945.
11. Chiodini RJ. Antimicrobial activity of rifabutin in combination with two and three other antimicrobial agents against strains of Mycobacterium paratuberculosis. J Antimicrob Chemother. 1991;27:171-176 10.1093/jac/27.2.171.
12. Collins LA, Torrero MN, Franzblau SG. Green fluorescent protein reporter microplate assay for high-throughput screening of compounds against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1998;42:344-347105411.
13. Curtis JM, Sternhagen V, Batts D. Acute renal failure after placement of tobramycin-impregnated bone cement in an infected total knee arthroplasty. Pharmacotherapy. 2005;25:876-880 10.1592/phco.2005.25.6.876.
14. Efstathopoulos N, Giamarellos-Bourboulis E, Kanellakopoulou K, Lazarettos I, Giannoudis P, Frangia K, Magnissalis E, Papadaki M, Nikolaou VS. Treatment of experimental osteomyelitis by methicillin resistant Staphylococcus aureus with bone cement system releasing grepafloxacin. Injury. 2008;39:1384-1390 10.1016/j.injury.2008.04.006.
15. Friedlaender GE, Schiller AL. Case records of the Massachusetts General Hospital: weekly clinicopathological exercises: case 43-1983: an elderly man with progressive pain and swelling of the knee. N Engl J Med. 1983;309:1042-1049 10.1056/NEJM198310273091708.
16. Galvez-Lopez R, Pena-Monje A, Antelo-Lorenzo R, Guardia-Olmedo J, Moliz J, Hernandez-Quero J, Parra-Ruiz J. Elution kinetics, antimicrobial activity, and mechanical properties of 11 different antibiotic loaded acrylic bone cement. Diagn Microbiol Infect Dis. 78:70-74.
17. Gonzalo X, Casali N, Broda A, Pardieu C, Drobniewski F. Combination of amikacin and doxycycline against multidrug-resistant and extensively drug-resistant tuberculosis. Int J Antimicrob Agents. 2015;45:406-412 10.1016/j.ijantimicag.2014.11.017.
18. Goodell JA, Flick AB, Hebert JC, Howe JG. Preparation and release characteristics of tobramycin-impregnated polymethylmethacrylate beads. Am J Hosp Pharm. 1986;43:1454-1461.
19. Goss B, Lutton C, Weinrauch P, Jabur M, Gillett G, Crawford R. Elution and mechanical properties of antifungal bone cement. J Arthroplasty. 2007;22:902-908 10.1016/j.arth.2006.09.013.
20. Han CD, Oh T, Cho SN, Yang JH, Park KK. Isoniazid could be used for antibiotic-loaded bone cement for musculoskeletal tuberculosis: an in vitro study. Clin Orthop Relat Res. 2013;471:2400-2406 10.1007/s11999-013-2899-53676586.
21. Ju HF, Wang XX, Li GL, Xie T, Zhao DF, Li SL, Li JX, Zhao H, Mu C. [Characteristics of Mycobacterium tuberculosis genotype and the relationship between Beijing genotype and drug-resistant phenotypes in Tianjin][in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2011;32:116-119.
22. Kaushik A, Makkar N, Pandey P, Parrish N, Singh U, Lamichhane G. Carbapenems and Rifampin exhibit synergy against Mycobacterium tuberculosis and Mycobacterium abscessus. Antimicrob Agents Chemother. 2015;59:6561-6567.
23. Klekamp J, Dawson JM, Haas DW, DeBoer D, Christie M. The use of vancomycin and tobramycin in acrylic bone cement: biomechanical effects and elution kinetics for use in joint arthroplasty. J Arthroplasty. 1999;14:339-346 10.1016/S0883-5403(99)90061-X.
24. Kotra LP, Haddad J, Mobashery S. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. Antimicrob Agents Chemother. 2000;44:3249-3256 10.1128/AAC.44.12.3249-3256.200090188.
25. Leclere LE, Sechriest VF 2nd, Holley KG, Tsukayama DT. Tuberculous arthritis of the knee treated with two-stage total knee arthroplasty: a case report. J Bone Joint Surg Am. 2009;91:186-191 10.2106/JBJS.G.01421.
26. Lee SH, Tai CL, Chen SY, Chang CH, Chang YH, Hsieh PH. Elution and mechanical strength of vancomycin-loaded bone cement: in vitro study of the influence of brand combination. PLoS One. 2016;11:e0166545 10.1371/journal.pone.01665455113949.
27. Liu BB, Lu LP, Lu B, Wan KL. Yan Y [Meta analysis on the correlation between Mycobacterium tuberculosis Beijing family strains and drug resistance][in Chinese]. Zhonghua Yu Fang Yi Xue Za Zhi 2012;46:158-164.
28. Liu Z, Pang Y, Chen S, Wu B, He H, Pan A, Wang X. A first insight into the genetic diversity and drug susceptibility pattern of Mycobacterium tuberculosis complex in Zhejiang. China. Biomed Res Int. 2016;2016:8937539.
29. Lynch M, Esser MP, Shelley P, Wroblewski BM. Deep infection in Charnley low-friction arthroplasty. comparison of plain and gentamicin-loaded cement. J Bone Joint Surg Br. 1987;69:355-360 10.2106/00004623-198769030-00006.
30. Martinez-Moreno J, Mura C, Merino V, Nacher A, Climente M, Merino-Sanjuan M. Study of the influence of bone cement type and mixing method on the bioactivity and the elution kinetics of ciprofloxacin. J Arthroplasty. 2015;30:1243-1249 10.1016/j.arth.2015.02.016.
31. Masri BA, Duncan CP, Beauchamp CP. Long-term elution of antibiotics from bone-cement: an in vivo study using the prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) system. J Arthroplasty. 1998;13:331-338 10.1016/S0883-5403(98)90179-6.
32. Masri BA, Duncan CP, Jewesson P, Ngui-Yen J, Smith J. Streptomycin-loaded bone cement in the treatment of tuberculous osteomyelitis: an adjunct to conventional therapy. Can J Surg. 1995;38:64-68.
33. McLaren RL, McLaren AC, Vernon BL. Generic tobramycin elutes from bone cement faster than proprietary tobramycin. Clin Orthop Relat Res. 2008;466:1372-1376 10.1007/s11999-008-0199-22384044.
34. Meyer J, Piller G, Spiegel CA, Hetzel S, Squire M. Vacuum-mixing significantly changes antibiotic elution characteristics of commercially available antibiotic-impregnated bone cements. J Bone Joint Surg Am. 2011;93:2049-2056 10.2106/JBJS.J.01777.
35. Miller R, McLaren A, Leon C, McLemore R. Mixing method affects elution and strength of high-dose ALBC: a pilot study. Clin Orthop Relat Res. 2012;470:2677-2683 10.1007/s11999-012-2351-23442001.
36. Mokrousov I. Mycobacterium tuberculosis phylogeography in the context of human migration and pathogen's pathobiology: insights from Beijing and Ural families. Tuberculosis (Edinb). 2015;95(suppl 1):S167-176.
37. Paz E, Sanz-Ruiz P, Abenojar J, Vaquero-Martin J, Forriol F, Real JC. Evaluation of elution and mechanical properties of high-dose antibiotic-loaded bone cement: comparative "in vitro" study of the influence of vancomycin and cefazolin. J Arthroplasty. 2015;30:1423-1429 10.1016/j.arth.2015.02.040.
38. Penner MJ, Masri BA, Duncan CP. Elution characteristics of vancomycin and tobramycin combined in acrylic bone-cement. J Arthroplasty. 1996;11:939-944 10.1016/S0883-5403(96)80135-5.
39. Pithankuakul K, Samranvedhya W, Visutipol B, Rojviroj S. The effects of different mixing speeds on the elution and strength of high-dose antibiotic-loaded bone cement created with the hand-mixed technique. J Arthroplasty. 2015;30:858-863 10.1016/j.arth.2014.12.003.
40. Qiu XS, Zheng X, Shi HF, Zhu YC, Guo X, Mao HJ, Xu GY, Chen YX. Antibiotic-impregnated cement spacer as definitive management for osteomyelitis. BMC Musculoskelet Disord. 2015;16:254 10.1186/s12891-015-0704-14570462.
41. Saavedra MJ, Borges A, Dias C, Aires A, Bennett RN, Rosa ES, Simoes M. Antimicrobial activity of phenolics and glucosinolate hydrolysis products and their synergy with streptomycin against pathogenic bacteria. Med Chem. 2010;6:174-183 10.2174/1573406411006030174.
42. Su JY, Huang TL, Lin SY. Total knee arthroplasty in tuberculous arthritis. Clin Orthop Relat Res. 1996;323:181-187 10.1097/00003086-199602000-00024.
43. Velayati AA, Masjedi MR, Farnia P, Tabarsi P, Ghanavi J, Ziazarifi AH, Hoffner SE. Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in Iran. Chest. 2009;136:420-425 10.1378/chest.08-2427.
44. Wilkinson MC. Synovectomy and curettage in the treatment of tuberculosis of joints. J Bone Joint Surg Br. 1953;35:209-223.
45. Yan AY, Faro FD, Schon LC. Using cement plugs in soft tissue infection and osteomyelitis. Orthopedics. 2014;37:32-36 10.3928/01477447-20131219-04.
46. Zhao W, Zheng M, Wang B, Mu X, Li P, Fu L, Liu S, Guo Z. Interactions of linezolid and second-line anti-tuberculosis agents against multidrug-resistant Mycobacterium tuberculosis in vitro and in vivo. Int J Infect Dis. 2016;52:23-28 10.1016/j.ijid.2016.08.027.
47. Zignol M, Dara M, Dean AS, Falzon D, Dadu A, Kremer K, Hoffmann H, Hoffner S, Floyd K. Drug-resistant tuberculosis in the WHO European region: an analysis of surveillance data. Drug Resist Updat. 2013;16:108-115 10.1016/j.drup.2014.02.003.
48. Zignol M, Dean AS, Alikhanova N, Andres S, Cabibbe AM, Cirillo DM, Dadu A, Dreyer A, Driesen M, Gilpin C, Hasan R, Hasan Z, Hoffner S, Husain A, Hussain A, Ismail N, Kamal M, Mansjo M, Mvusi L, Niemann S, Omar SV, Qadeer E, Rigouts L, Ruesch-Gerdes S, Schito M, Seyfaddinova M, Skrahina A, Tahseen S, Wells WA, Mukadi YD, Kimerling M, Floyd K, Weyer K. Raviglione MC. Population-based resistance of mycobacterium tuberculosis isolates to pyrazinamide and fluoroquinolones: results from a multicountry surveillance project. Lancet Infect Dis. 2016;16:1185-1192 10.1016/S1473-3099(16)30190-65030278.
49. Zignol M, Gemert W, Falzon D, Sismanidis C, Glaziou P, Floyd K. Raviglione M. Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010. Bull World Health Organ. 2012;90:111-119d 10.2471/BLT.11.092585.
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Language: | English.
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Document Type: | Basic Research.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0009-921X
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NLM Journal Code: | 0075674, dfy
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DOI Number: | https://dx.doi.org/10.1007/s1199...- ouverture dans une nouvelle fenêtre
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