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We report the hybrid FDG PET/CT appearance of a biopsy-proven pancreatic metastasis from prostate cancer in a man with castrate-resistant metastatic disease. The common sites of metastases from prostate cancer are bone and locoregional lymph nodes. Pancreas is an atypical location of metastasis from prostate cancer. PET/CT in this case helped with the targeted pathologic confirmation to differentiate primary pancreatic tumor from an unusual metastasis from prostate cancer which in turn affected the clinical management.

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