Information de reference pour ce titreAccession Number: | 00003040-200204000-00003.
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Author: | LU, F. X 1 2; ABEL, K 1 2; MA, Z 1; ROURKE, T 1 2; LU, D 1; TORTEN, J 1; MCCHESNEY, M 1; MILLER, C. J 1 2 3
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Institution: | (1)California Regional Primate Research Center; (2)Center for Comparative Medicine and (3)Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, CA, USA
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Title: | |
Source: | Clinical & Experimental Immunology. 128(1):10-20, April 2002.
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Abstract: | SUMMARY: To understand more clearly how mucosal and systemic immunity is regulated by ovarian steroid hormones during the menstrual cycle, we evaluated the frequency of immunoglobulin- and antibody-secreting cells (ISC, AbSC) in genital tract and systemic lymphoid tissues of normal cycling female rhesus macaques. The frequency of ISC and AbSC was significantly higher in tissues collected from animals in the periovulatory period of the menstrual cycle than in tissues collected from animals at other stages of the cycle. The observed changes were not due to changes in the relative frequency of lymphocyte subsets and B cells in tssues, as these did not change during the menstrual cycle. In vitro, progesterone had a dose-dependent inhibitory effect, and oestrogen had a dose-dependent stimulatory effect on the frequency of ISC in peripheral blood mononuclear cell (PBMC) cultures. The in vitro effect of progesterone and oestrogen on ISC frequency could not be produced by incubating enriched B cells alone with hormone, but required the presence of CD8+ T cells. Following oestrogen stimulation, a CD8+ enriched cell population expressed high levels of IFN-gamma and IL-12. The changes in B cell Ig secretory activity that we document in the tissues of female rhesus macaques during the menstrual cycle is due apparently to the action of ovarian steroid hormones on CD8+ T cells. Thus, CD8+ T cells control B cell secretory activity in both mucosal and systemic immune compartments. Understanding, and eventually manipulating, the CD8+ regulatory cell-B cell interactions in females may produce novel therapeutic approaches for autoimmune diseases and new vaccine strategies to prevent sexually transmitted diseases.
(C) 2002 Blackwell Science Ltd.
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Author Keywords: | CD8+ T cell; immunoglobulin-secreting cell; interferon-gamma; oestrogen; progesterone.
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Language: | English.
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Document Type: | Animal studies.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0009-9104
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NLM Journal Code: | dd7, 0057202
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