Information de reference pour ce titreAccession Number: | 00002515-200503000-00005.
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Author: | Noora, Joseph M.D. *,+; Ricci, Christopher M.D. *,+; Hastings, Deborah M.D. *,+; Hill, Stephen Ph.D. +; Cybulsky, Irene M.D. *,+
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Institution: | *McMaster University, Hamilton, Ontario, Canada +Hamilton Health Sciences, Hamilton, Ontario, Canada
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Title: | Determination of Troponin I Release After CABG Surgery.[Article]
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Source: | Journal of Cardiac Surgery. 20(2):129-135, March/April 2005.
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Abstract: | Background: Troponin I is used to diagnose myocardial infarction (MI). Its use and pattern of elevation is not well defined in coronary artery bypass graft (CABG) surgery. This study assessed the timing of troponin I elevation in patients undergoing urgent CABG.
Method: Patients undergoing urgent isolated-CABG with cardiopulmonary bypass were studied prospectively. Blood samples were taken to measure CK, CK-MB, and troponin I: preoperatively, 7 hours postoperatively, 14 to 18 hours postoperatively, 30 to 48 hours postoperatively, and on postoperative day 4. Electrocardiograms and in-hospital course were recorded. Perioperative MI (PMI) was defined by either (i) ECG criteria of new Q-waves in the presence of CK-MB elevation >50 [mu]g/L or (ii) CK-MB > 100 [mu]g/L.
Results: Of the 50 patients studied, 6 met the criteria for PMI (12%); 2 by criteria (i) and 4 by criteria (ii). In patients not meeting the criteria for MI the troponin I level peaked at 7 hour post-op with a mean of 20.97 [mu]g/L (95% CI, 17.11 to 24.83). At this time, patients who met the criteria for MI had a mean troponin I level of 46.85 [mu]g/L (95% CI, 36.40 to 57.30). Of variables investigated for the 44 patients who did not meet MI criteria, only preoperative troponin I level impacted peak postoperative troponin I.
Conclusions: CABG elevates troponin I far beyond current diagnostic benchmarks without the clinical occurrence of a MI and appears to peak during the second postoperative day. An elevated preoperative troponin I may predict an elevated peak postoperative troponin I in patients who do not have a PMI.
Copyright (C) 2005 Blackwell Publishing Ltd.
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Language: | English.
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Document Type: | ORIGINAL ARTICLE.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0886-0440
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NLM Journal Code: | ben, 8908809
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