The Impact of Preoperative Serum Anti-TNF[alpha] Therapy Levels on Early Postoperative Outcomes in Inflammatory Bowel Disease Surgery.
Lau, Cheryl MD *; Dubinsky, Marla MD +; Melmed, Gil MD ++; Vasiliauskas, Eric MD ++; Berel, Dror MS ++; McGovern, Dermot MD, PhD ++; Ippoliti, Andrew MD ++; Shih, David MD, PhD ++; Targan, Stephan MD ++; Fleshner, Phillip MD *
Annals of Surgery.
261(3):487-496, March 2015.
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Objective: Assess the impact of preoperative serum antitumor necrosis factor-[alpha] (anti-TNF[alpha]) drug levels on 30-day postoperative morbidity in inflammatory bowel disease (IBD) patients.
Background: Studies on the association of anti-TNF[alpha] drugs and postoperative outcomes in IBD are conflicting due to variable pharmacokinetics of anti-TNF[alpha] drugs. It remains to be seen whether preoperative serum anti-TNF[alpha] drug levels correlate with postoperative morbidity.
Methods: Thirty-day postoperative outcomes of consecutive IBD surgical patients with serum drawn within 7 days preoperatively were studied. The total serum level of 3 anti-TNF[alpha] drugs (infliximab, adalimumab, and certolizumab) was measured, with >=0.98 [mu]g/mL considered as detected. Data were also reviewed according to a clinical cutoff value of 3 [mu]g/mL.
Results: A total of 217 patients [123 with Crohn disease (CD) and 94 with ulcerative colitis (UC)] were analyzed; 75 of 150 (50%) treated with anti-TNF[alpha] therapy did not have detected levels at the time of surgery. In the UC cohort, adverse postoperative outcome rates between the undetectable and detectable groups were similar when stratified according to type of UC surgery. In the CD cohort, there was a higher but statistically insignificant rate of adverse outcomes in the detectable versus undetectable groups. Using a cut off level of 3 [mu]g/mL, postoperative morbidity (odds ratio [OR] = 2.5, P = 0.03) and infectious complications (OR = 3.0, P = 0.03) were significantly higher in the >=3 [mu]g/mL group. There were higher rates of postoperative morbidity (P = 0.047) and hospital readmissions (P = 0.04) in the >=8 [mu]g/mL compared with <3 [mu]g/mL group.
Conclusions: Increasing preoperative serum anti-TNF[alpha] drug levels are associated with adverse postoperative outcomes in CD but not UC patients.
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