Information de reference pour ce titreAccession Number: | 00000465-200904000-00016.
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Author: | Kleinhans, Natalia M. Ph.D.; Johnson, L. Clark Ph.D.; Richards, Todd Ph.D.; Mahurin, Roderick Ph.D.; Greenson, Jessica Ph.D.; Dawson, Geraldine Ph.D.; Aylward, Elizabeth Ph.D.
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Institution: | From the Department of Radiology, the Department of Psychosocial and Community Health, the Center on Human Development and Disability, and the Autism Center, University of Washington, Seattle; and Autism Speaks, New York City.
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Title: | Reduced Neural Habituation in the Amygdala and Social Impairments in Autism Spectrum Disorders.[Article]
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Source: | American Journal of Psychiatry. 166(4):467-475, April 2009.
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Abstract: | Objective: Amygdala dysfunction has been proposed as a critical component in social impairment in autism spectrum disorders. This study was designed to investigate whether abnormal habituation characterizes amygdala dysfunction in autism spectrum disorders and whether the rate of amygdala habituation is related to social impairment.
Method: Using functional MRI, the authors measured change over time in activation of the amygdala and fusiform gyrus to neutral facial stimuli in adults with autism spectrum disorders and healthy comparison adults.
Results: The comparison group evidenced significantly greater amygdala habituation bilaterally than the autism spectrum group. There were no group differences in overall fusiform habituation. For the autism spectrum group, lower levels of habituation of the amygdala to the face stimuli were associated with more severe social impairment.
Conclusions: These results suggest amygdala hyperarousal in autism spectrum disorders in response to socially relevant stimuli. Further, sustained amygdala arousal may contribute to the social deficits observed in autism spectrum disorders.
Copyright (C) 2009 American Psychiatric Association.
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Language: | English.
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Document Type: | New Research: Article.
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Journal Subset: | Clinical Medicine. Behavioral & Social Sciences.
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ISSN: | 0002-953X
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NLM Journal Code: | 0370512, 3vg
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