Unique Lipid A Modifications in Pseudomonas aeruginosa Isolated from the Airways of Patients with Cystic Fibrosis.
Ernst, Robert K. 1; Moskowitz, Samuel M. 2; Emerson, Julia C. 2; Kraig, Gretchen M. 1; Adams, Kristin N. 1; Harvey, Megan D. 1; Ramsey, Bonnie 2; Speert, David P. 5; Burns, Jane L. 2; Miller, Samuel I. 1,3,4
[Report] Journal of Infectious Diseases. 196(7):1088-1092, October 1, 2007.

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: Three structural features of lipid A (addition of palmitate [C16 fatty acid], addition of aminoarabinose [positively charged amino sugar residue], and retention of 3-hydroxydecanoate [3-OH C10 fatty acid]) were determined for Pseudomonas aeruginosa isolates from patientswith cystic fibrosis (CF; n = 86), from the environment (n = 13), and from patients with other conditions (n = 14). Among P. aeruginosa CF isolates, 100% had lipid A with palmitate, 24.6% with aminoarabinose, and 33.3% retained 3-hydroxydecanoate. None of the isolates from the environment or from patients with other conditions displayed these modifications. These results indicate that unique lipid A modifications occur in clinical P. aeruginosa CF isolates.

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