Antigen-Specific B-Cell Response to 13-Valent Pneumococcal Conjugate Vaccine in Asplenic Individuals With [beta]-Thalassemia Previously Immunized With 23-Valent Pneumococcal Polysaccharide Vaccine.
Papadatou, Ioanna 1; Piperi, Cristina 2; Alexandraki, Krystallenia 2; Kattamis, Antonis 3; Theodoridou, Maria 1; Spoulou, Vana 1
[Report]
Clinical Infectious Diseases.
59(6):862-865, September 15, 2014.
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Current guidelines recommend a combined schedule of a 13-valent pneumococcal conjugate vaccine (PCV13) and PPSV23 (23-valent polysaccharide vaccine) for asplenic individuals. We show that PCV13 induces a T-dependent immune response in asplenic individuals with [beta]-thalassemia, but previous PPSV23s affect the memory B-cell response in a dose- and time-dependent manner.
Clinical Trials Registration. NCT01846923.
(C) Copyright Oxford University Press 2014.