Divide and conquer: the genetic basis of molecular subclassification of breast cancer.
Kristensen, Vessela N. 1,*
[Miscellaneous Article] Embo Molecular Medicine. 3(4):183-185, April 2011.

(Format: HTML, PDF)

: Since the luminal B tumours are associated with poor recurrence-free and disease-specific survivals in all adjuvant systemic treatment categories including hormone therapy, the identification of specific signalling pathways driving luminal B biology is paramount to improve treatment. Sircoulomb et al. and Holland et al. have independently identified the ZNF703 gene, located in chromosomal region 8p12, as preferentially amplified in luminal B tumours.

Copyright (C) 2011 John Wiley & Sons, Inc.