Prognostic Relevance of 6q Deletion in Waldenstrom's Macroglobulinemia: A Multicenter Study.
Chang, Hong 1; Qi, Connie 1; Trieu, Young 1; Jiang, Allan 1; Young, Ken H. 2; Chesney, Alden 3; Jani, Prashant 4; Wang, Chen 5; Reece, Donna 1; Chen, Christine 1
Clinical Lymphoma & Myeloma.
9(1):36-38, March 2009.
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: The deletion of the long arm of chromosome 6 is the most common cytogenetic abnormality in Waldenstrom's macroglobulinemia (WM), but its prognostic significance is unclear. We investigated 77 patients with WM by interphase cytoplasmic immunoglobulin M fluorescence in situ hybridization (cIgM-FISH) and correlated the 6q status with the patients' clinical features and survival. cIg-FISH detected hemizygous 6q deletions in 32 patients (41.6%). The 6q deletions were correlated with higher C-reactive protein levels (P = .02) and CD23 expression (P = .03) but not with other clinical laboratory features of WM. There was no significant difference in time to the initial treatment between deleted and non-deleted groups (median, 5.6 months vs. 2.6 months; P = .46), or overall survivals in patients with and without del (6q) (163 months vs. not reached; P = .83). Our study confirms that the 6q deletion is a frequent event, but it does not appear to affect the clinical outcome of WM.
(C) 2009 CIG Media Group, lp.