Antitumor effects of [alpha]-bisabolol against pancreatic cancer.
Seki, Takashi 1; Kokuryo, Toshio 1,3; Yokoyama, Yukihiro 1; Suzuki, Hisanori 2; Itatsu, Keita 1; Nakagawa, Akifumi 1; Mizutani, Tetsushi 1; Miyake, Takashi 1; Uno, Masanori 1; Yamauchi, Kohei 1; Nagino, Masato 1
[Article] Cancer Science. 102(12):2199-2205, December 2011.

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: In the present study, we investigated whether [alpha]-bisabolol, a sesquiterpene alcohol present in essential oils derived from a variety of plants, has antitumor effects against pancreatic cancer. [alpha]-Bisabolol induced a decrease in cell proliferation and viability in pancreatic cancer cell lines (KLM1, KP4, Panc1, MIA Paca2), but not in pancreatic epithelial cells (ACBRI515). [alpha]-Bisabolol treatment induced apoptosis and suppressed Akt activation in pancreatic cancer cell lines. Furthermore, [alpha]-bisabolol treatment induced the overexpression of early growth response-1 (EGR1), whereas EGR1 siRNA decreased the [alpha]-bisabolol-induced cell death of KLM1 cells. Tumor growth in both subcutaneous and peritoneal xenograft nude mouse models was significantly inhibited by intragastric administration of 1000 mg/kg of [alpha]-bisabolol, once a week for three weeks. The results indicate that [alpha]-bisabolol could be a novel therapeutic option for the treatment of pancreatic cancer. (Cancer Sci 2011; 102: 2199-2205)

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