Total-tau and neurofilament light in CSF reflect spinal cord ischaemia after endovascular aortic repair.
Merisson, Edyta; Mattsson, Niklas; Zetterberg, Henrik; Blennow, Kaj; Pikwer, Andreas; Mehmedagic, Irma; Acosta, Stefan; Akeson, Jonas
[Article] Neurochemistry International. 93 Supplement C:1-5, February 2016.

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Background: Repair of extensive aortic disease may be associated with spinal cord ischaemia (SCI). Here we test if levels of cerebrospinal fluid (CSF) biomarkers for neuronal injury are altered in patients with SCI after advanced endovascular repair in extensive aortic disease.

Methods: CSF was sampled for up to 48 h in ten patients undergoing endovascular aortic repair and analyzed for the axonal damage markers total-tau (T-tau) and neurofilament light (NFL).

Results: Six of ten patients developed SCI (clinically present within 3-6 h). CSF levels of NFL increased up to 37-fold in patients with, but were stable in patients without, SCI. CSF levels of T-tau also increased in patients with SCI, but with some overlap with patients without SCI. Levels of NFL and T-tau did not increase until after the appearance of clinical signs of neurological dysfunction (12-48 h after aortic repair).

Conclusions: The CSF biomarkers NFL and T-tau both reflect development of SCI after endovascular aortic repair, but do not rise until after clinical signs of SCI appear. Future studies are desirable to further evaluate potential use of these biomarkers for assessment of the severity of SCI, and also to identify earlier biomarkers of SCI.

Highlights:

* Levels of biomarkers of neuronal injury are quantifiable in CSF after aortic surgery.

* Increased CSF levels of neurofilament light reflect clinical signs of spinal dysfunction.

* Future studies should aim at finding earlier clinical biomarkers of spinal cord injury.

(C) 2016Elsevier, Inc.