Pyridoxal 5'-Phosphate as a Catalytic and Conformational Cofactor of Muscle Glycogen Phosphorylase b.
Livanova, N. B. *; Chebotareva, N. A.; Eronina, T. B.; Kurganov, B. I.
[Review] Biochemistry (Moscow). Biochemistry (Moscow). 67(10):1089-1098, October 2002.

(Format: HTML, PDF)

This review summarizes data on structure of muscle glycogen phosphorylase b and the role of the cofactor pyridoxal 5'-phosphate in catalysis and stabilizing the native conformation of the enzyme. Specific attention is paid to the stabilizing role of pyridoxal 5'-phosphate upon denaturation of phosphorylase b. Stability of holoenzyme, apoenzyme, and enzyme reduced by sodium borohydride is compared.

(C)2002 Kluwer Academic Publishers