Desired Vancomycin Trough Serum Concentration for Treating Invasive Methicillin-resistant Staphylococcal Infections.
Frymoyer, Adam MD *; Guglielmo, B. Joseph PharmD +; Hersh, Adam L. MD, PhD ++
[Review] Pediatric Infectious Disease Journal. 32(10):1077-1079, October 2013.

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Vancomycin area under the curve/minimal inhibitory concentration (AUC/MIC) >400 best predicts the outcome when treating invasive methicillin-resistant Staphylococcus aureus infection; however, trough serum concentrations are used clinically to assess the appropriateness of dosing. We used pharmacokinetic modeling and simulation to examine the relationship between vancomycin trough values and AUC/MIC in children receiving vancomycin 15 mg/kg every 6 hours and methicillin-resistant Staphylococcus aureus MIC of 1 [mu]g/mL. A trough of 7-10 [mu]g/mL predicted achievement of AUC/MIC >400 in >90% of children.

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