Information de reference pour ce titreAccession Number: | 00005064-200209060-00022.
|
Author: | Castegna, Alessandra *; Aksenov, Michael +; Thongboonkerd, Visith ++; Klein, Jon B. ++; Pierce, William M. [S]; Booze, Rosemarie +; Markesbery, William R. [P],**; Butterfield, D. Allan *,[P]
|
Institution: | *Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington, Kentucky, USA +Departments of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA [P]Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA **Departments of Pathology and Neurology, University of Kentucky, Lexington, Kentucky, USA ++Kidney Disease Program and Proteomics Core Laboratory, Louisville, Kentucky, USA [S]Department of Pharmacology, University of Louisville School of Medicine and VAMC, Louisville, Kentucky, USA
|
Title: | |
Source: | Journal of Neurochemistry. 82(6):1524-1532, September 2002.
|
Abstract: | Alzheimer's disease (AD) is a neurodegenerative disorder in which oxidative stress has been implicated as an important event in the progression of the pathology. In particular, it has been shown that protein modification by reactive oxygen species (ROS) occurs to a greater extent in AD than in control brain, suggesting a possible role for oxidation-related decrease in protein function in the process of neurodegeneration. Oxidative damage to proteins, assessed by measuring the protein carbonyl content, is involved in several events such as loss in specific protein function, abnormal protein clearance, depletion of the cellular redox-balance and interference with the cell cycle, and, ultimately, neuronal death. The present investigation represents a further step in understanding the relationship between oxidative modification of protein and neuronal death in AD. Previously, we used our proteomics approach, which successfully substitutes for labor-intensive immunochemical analysis, to detect proteins and identified creatine kinase, glutamine synthase and ubiquitin carboxy-terminal hydrolase L-1 as specifically oxidized proteins in AD brain. In this report we again applied our proteomics approach to identify new targets of protein oxidation in AD inferior parietal lobe (IPL). The dihydropyrimidinase related protein 2 (DRP-2), which is involved in the axonal growth and guidance, showed significantly increased level in protein carbonyls in AD brain, suggesting a role for impaired mechanism of neural network formation in AD. Additionally, the cytosolic enzyme [alpha]-enolase was identified as a target of protein oxidation and is involved the glycolytic pathway in the pathological events of AD. Finally, the heat shock cognate 71 (HSC-71) revealed increased, but not significant, oxidation in AD brain. These results are discussed with reference to potential involvement of these oxidatively modified proteins in neurodegeneration in AD brain.
(C) 2002 International Society for Neurochemistry
|
Author Keywords: | Alzheimer's disease; neurodegenerative mechanisms; protein oxidation; proteomics.
|
References: | Akcetin Z., Pregla R., Darmer D., Heynemann H., Haerting J., Bromme H. J. and Holtz J. (1999) Differential expression of heat shock proteins 70-1 and 70-2 mRNA after ischemia-reperfusion injury of rat kidney. Urol. Res. 27, 306-311.
Aksenov M. Y., Aksenova M. V., Butterfield D. A. and Markesbery W. R. (2000) Oxidative modification of creatine kinase BB in Alzheimer's disease brain. J. Neurochem. 74, 2520-2527.
Aksenov M. Y., Aksenova M. V., Butterfield D. A., Geddes J. W. and Markesbery W. R. (2001) Protein oxidation in the brain in Alzheimer's disease. Neuroscience 103, 373-383.
Alderman C. J., Shah S., Foreman J. C. and Chain B. M. and. Katz D. R. (2002) The role of advanced oxidation protein products in regulation of dendritic cell function. Free Radic. Biol. Med. 32, 377-385.
Becker L., Mito T., Takashima S. and Onodera K. (1991) Growth anddevelopment of the brain in Down syndrome, in The Morphogenesis of Down Syndrome (Epstein C. J., ed.), p. 133, Wiley-Liss, New York.
Berlett B. S. and Stadtman E. R. (1997) Protein oxidation in aging, disease, and oxidative stress. J. Biol. Chem. 272, 20313-20316.
Butterfield D. A. and Kanski J. (2001) Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins. Mech. Ageing Dev. 122, 945-962.
Butterfield D. A. and Lauderback C. M. (2002) Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid [beta]-peptide-associated free radical oxidative stress. Free Rad. Biol. Med. 32, 1050-1060.
Butterfield D. A. and Stadtman E. R. (1997) Protein oxidation processes in aging brain. Adv. Cell Aging Gerontol. 2, 161-191.
Butterfield D. A., Hensley K., Cole P., Subramaniam R., Aksenov M., Aksenova M., Bummer P. M., Haley B. E. and Carney J. M. (1997) Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: relevance to. Alzheimer's disease. J. Neurochem. 68, 2451-2457.
Butterfield D. A., Drake J., Pocernich C. and Castegna A. (2001) Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends Mol. Med. 7, 548-554.
Castegna A., Aksenov M., Aksenova M., Thongboonkerd V., Klein J. B., Pierce W. M., Booze R., Markesbery W. M. and Butterfield D. A. (2002) Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Free Rad. Biol. Med. 33, 562-571.
Dean R. T., Fu S., Stocker R. and Davies M. J. (1997) Biochemistry and pathology of radical-mediated protein oxidation. Biochem. J. 324, 1-18.
Desai C., Garriga G., McIntire S. L. and Horvitz H. R. (1988) A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Nature 336, 638-646.
Dworniczak B. and Mirault M. E. (1987) Structure and expression of a human gene coding for a 71 kD heat shock 'cognate' protein. Nucleic Acids Res. 15, 5181-5197.
Goshima Y., Nakamura F., Strittmatter P. and Strittmatter S. M. (1995) Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. Nature 376, 509-514.
Gu Y. and Ihara Y. (2000) Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules. J. Biol. Chem. 275, 17917-17920.
Gu Y., Hamajima N. and Ihara Y. (2000) Neurofibrillary tangle-asociated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, ser-518 and ser-522. Biochemistry 39, 4267-4275.
Hamajima N., Matsuda K., Sakata S., Tamaki N. and Sasaki M. and Nonaka M. (1996) A novel gene family defined by human dihydropyrimidinase and the three related proteins with differential tissue distribution. Gene 180, 157-163.
Hedgecock E. M., Culotti J. G., Thomson J. N. and Perkins L. A. (1985) Axonal guidance mutants of Caenorhabditis elegans identified by filling sensory neurons with fluorescein dyes. Dev Biol. 111, 158-170.
Hensley K., Hall N., Subramaniam R., Cole P., Harris M., Aksenov M., Aksenova M., Gabbita P., Wu J. F., Carney J. M., Lovell M., Markesbery W. R. and Butterfield D. A. (1995) Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J. Neurochem. 65, 2146-2156.
Kamata H. and Hirata H. (2001) Redox regulation of cellular signalling. Cell. Signal. 11, 1-14.
Keller A., Berod A., Dussaillant M., Lamande N., Gros F. and Lucas M. (1994) Coexpression of alpha and gamma enolase genes in neurons of adult rat brain. J. Neurosci. Res. 38, 493-504.
Kouchi Z., Sorimachi H., Suzuki K. and Ishiura S. (1999) Proteasome inhibitors induce the association of Alzheimer's amyloid precursor protein with Hsc73. Biochem. Biophys. Res. Commun. 254, 804-810.
Leonarduzzi G., Arkan M. C., Basaga H., Chiarpotto E., Sevanian A. and Poli G. (2000) Lipid oxidation products in cell signaling. Free Rad Biol. Med. 28, 1370-1378.
Levine R. L., Williams J. A., Stadtman E. R. and Shacter E. (1994) Carbonyl assays for determination of oxidatively modified proteins. Meth Enzymol. 233, 346-357.
Lovis C., Mach F., Donati Y. R., Bonventre J. V. and Polla B. S. (1994) Heat shock proteins and the kidney. Ren. Fail. 16, 179-192.
Lubec G., Nonaka M., Krapfenbauer K., Gratzer M., Cairns N. and Fountoulakis M. (1999) Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down syndrome and Alzheimer's disease brain is downregulated at the mRNA and dysregulated at the protein level. J. Neural Transm. Supplement 57, 161-177.
Markesbery W. R. (1997) Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 23, 134-147.
McKhann G., Drachman D., Folstein M., Katzman R., Price D. and Stadlan E. M. (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Service Task Force on Alzheiemer's disease. Neurology 34, 939-944.
Messier G. and Gagnon M. (1996) Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes. Behav. Brain Res. 75, 1-11.
Mielke R., Schroder R., Fink G. R., Kessler J., Herholz K. and Heiss W. D. (1996) Regional cerebral glucose metabolism and postmortem pathology in Alzheimer's disease. Acta Neuropathol. (Berlin) 91, 174-179.
Minturn J. E., Fryer H. J., Geschwind D. H. and Hockfield S. (1995) TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth. J. Neurosci. 15, 6757-6766.
Mosser D. D., Caron A. W., Bourget L., Denis-Larose C. and Massie B. (1997) Role of the human heat shock protein hsp70 in protectionagainst stress-induced apoptosis. Mol. Cell Biol. 17, 5317-5327.
Mosser D. D., Caron A. W., Bourget L., Meriin A. B., Sherman M. Y., Morimoto R. I. and Massie B. (2000) The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol. Cell Biol. 20, 7146-7159.
Muller B. K., Bonhoeffer F. and Drescher U. (1996) Novel gene families involved in neural pathfinding. Curr. Opin. Genet. Dev. 6, 469-474.
National Institute on Aging and the Reagan Institute Working Group (1997) Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. Neurobiol. Aging 18, S1-S2.
Schmechel D. E., Marangos P. J., Martin B. M., Winfield S., Burkhart D. S., Roses A. D. and Ginns E. I. (1987) Localization of neuron-specific enolase (NSE) mRNA in human brain. Neurosci. Lett. 76, 233-238.
Schonberger S. J., Edgar P. F., Kydd R., Faull R. L. and Cooper G. J. (2001) Proteomic analysis of the brain in Alzheimer's disease: molecular phenotype of a complex disease process. Proteomics 1, 1519-1528.
Schoonbroodt S. and Piette J. (2000) Oxidative stress interference with the nuclear factor-kappa B activation pathways. Biochem. Pharmacol. 60, 1075-1083.
Sohal R. S., Agarwal S. and Sohal B. H. (1995) Oxidative stress and aging in mongolian gerbil (Meriones unguiculatus). Mech. Ageing Dev. 81, 15-25.
Stadtman E. R. (1990) Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences. Free Radic. Biol. Med. 9, 315-325.
Wang L. H. and Strittmatter S. M. (1996) A family of rat CRMP genes is differentially expressed in the nervous system. J. Neurosci. 16, 6197-6207.
Weitzdoerfer R., Fountoulakis M. and Lubec G. (2001) Aberrant expression of dihydropyrimidinase related proteins-2, -3 and -4 in fetal Down syndrome brain. J. Neural Trasm. Supplement 61, 95-107.
Yan L., Levine R. L. and Sohal R. S. (1997) Oxidative damage during aging targets mitochondrial aconitase. Proc. Natl Acad. Sci. USA 94, 11168-11172.
Yoo B. C., Kim S. H., Cairns N., Fountoulakis M. and Lubec G. (2001) Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease. Electrophoresis 280, 249-250.
Yoshida H., Watanabe A. and Ihara Y. (1998) Collapsin response mediator protein-2 is associated with neurofibrillary tangles in Alzheimer's disease. J. Biol. Chem. 273, 9761-9768.
|
Language: | English.
|
Document Type: | Original Articles.
|
Journal Subset: | Clinical Medicine. Behavioral & Social Sciences.
|
ISSN: | 0022-3042
|
NLM Journal Code: | jav, 2985190r
|
Annotation(s) | |
|
|