Antibody-secreting plasma cells persist for decades in human intestine.
Landsverk, Ole J.B. 1; Snir, Omri 2; Casado, Raquel Bartolome 1,*; Richter, Lisa 1,*; Mold, Jeff E. 5; Reu, Pedro 5,6; Horneland, Rune 7; Paulsen, Vemund 7; Yaqub, Sheraz 8; Aandahl, Einar Martin 4,7; Oyen, Ole M. 7; Thorarensen, Hildur Sif 9; Salehpour, Mehran 10; Possnert, Goran 10; Frisen, Jonas 5; Sollid, Ludvig M. 3,**; Baekkevold, Espen S. 1,**; Jahnsen, Frode L. 1,**
[Article] Journal of Experimental Medicine. 214(2):309-317, February 2017.

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Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets: a CD19 PC subset was dynamically exchanged, whereas of two CD19- PC subsets, CD45 PCs exhibited little and CD45- PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45- PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19- PC subsets support selection and maintenance of protective PCs for life in human intestine.

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