Information de reference pour ce titreAccession Number: | 00002328-200102000-00018.
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Author: | Orlandi, Ester 1; Paulli, Marco 2; Viglio, Alessandra 2; Pagnucco, Guido 1; Riboni, Roberta 2; Baldanti, Fausto 3; Lazzarino, Mario 1
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Institution: | (1)Institute of Haematology, University of Pavia, and Division of Haematology, (2)Anatomic Pathology Service, and (3)Viral Diagnostic Service, IRCCS Policlinico S. Matteo, Pavia, University of Pavia, Italy
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Title: | |
Source: | British Journal of Haematology. 112(2):373-376, February 2001.
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Abstract: | We report on a patient with follicular non-Hodgkin's lymphoma (NHL) who developed a fatal high-grade Epstein-Barr virus (EBV)-positive NHL after conventional chemotherapies. The sudden onset of the high-grade lymphoma was accompanied by increasing circulating EBV genome copies and was complicated by spontaneous rupture of the spleen. Splenic tissue was diffusely infiltrated by large B cells. In situ hybridization for Epstein-Barr-encoded RNA (EBER) 1-2 was positive in 70% of cells, and molecular analysis revealed the presence of EBV DNA and a monoclonal IgH gene rearrangement. This case shows that the immunosuppression of multiple treatments may induce uncontrolled reactivation of a latent EBV infection, contributing to high-grade transformation in heavily treated lymphoma patients.
(C) 2001 Blackwell Science Ltd.
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Author Keywords: | EBV-positive lymphoma; immunosuppression; chemotherapy.
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Language: | English.
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Document Type: | Haematological Malignancy: Short Report.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0007-1048
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NLM Journal Code: | axc, 0372544
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