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HIV progressive multifocal leukoencephalopathy (PML) patients had a significantly lower expression of CD62L on CD4 T cells (P < 0.001) when compared with HIV patients who did not develop PML. CD62L expression on CD4 T cells did not correlate with parameters such as CDC stage, CD4 cell percentage (of total CD3 T cells), CD4 cell counts, virus count, or clinical parameters. Measurement of CD62L might provide a biomarker for PML risk and could prompt a treatment change and/or close monitoring.

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