A Prospective, Randomized, Double-Blind, Placebo-Controlled Study of the Platelet and Global Hemostatic Effects of Ganoderma Lucidum (Ling-Zhi) in Healthy Volunteers.
Kwok, Yung FHKCA; Ng, Kwok F. J. FANZCA; Li, Carina C. F. FANZCA; Lam, Clarence C. K. MRCPath; Man, Ricky Y. K. PhD
Anesthesia & Analgesia.
101(2):423-426, August 2005.
(Format: HTML, PDF)
Ganoderma lucidum is a Chinese herbal medicine popular with cancer patients. Previous in vitro studies suggested that Ganoderma lucidum might impair hemostasis. In this prospective, randomized double-blind study, healthy volunteers received orally Ganoderma lucidum capsules 1.5 g (n = 20) or placebo (n = 20) daily for 4 wk. We monitored subjects before drug administration and at 4 and 8 wk thereafter by routine coagulation screen, fibrinogen concentration, von Willebrand ristocetin cofactor activity, platelet function analyzer PFA-100(R), and thrombelastography. There were no significant between-group differences and all measurements remained within the normal range. Ganoderma lucidum ingestion over 4 wk was not associated with impairment of hemostasis.
(C) 2005 International Anesthesia Research Society